ArticleJournal of bacteriology1999
Transcription regulation of the colicin K cka gene reveals induction of colicin synthesis by differential responses to environmental signals.
Article in Journal of bacteriology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Sulfoquinovose Catabolism inInternational journal of molecular sciences · 2025Article
- Design of Novel Saposin-like Bacteriocins Using a Hybrid Approach.Probiotics and antimicrobial proteins · 2025Article
- The strength of interspecies interaction in a microbial community determines its susceptibility to invasion.PLoS biology · 2024Article
- Bacterial defences: mechanisms, evolution and antimicrobial resistance.Nature reviews. Microbiology · 2023Review
- Colicin E2 expression in Escherichia coli biofilms: Induction and regulation revisited.Current research in microbial sciences · 2022Article
- Escherichia coli Strains Producing Selected Bacteriocins Inhibit Porcine Enterotoxigenic Escherichia coli (ETEC) under bothApplied and environmental microbiology · 2021Article
- The Evolution of Mass Cell Suicide in Bacterial Warfare.Current biology : CB · 2020Article
- Article
- Reporters for Single-Cell Analysis of Colicin Ib Expression in Salmonella enterica Serovar Typhimurium.PloS one · 2015Article
- A new biofilm-associated colicin with increased efficiency against biofilm bacteria.The ISME journal · 2014Article
- Global transcriptional responses to the bacteriocin colicin M in Escherichia coli.BMC microbiology · 2013Article
- DNA sampling: a method for probing protein binding at specific loci on bacterial chromosomes.Nucleic acids research · 2009Article
- Heterogeneity in expression of the Escherichia coli colicin K activity gene cka is controlled by the SOS system and stochastic factors.Molecular genetics and genomics : MGG · 2007Article
- Colicin biology.Microbiology and molecular biology reviews : MMBR · 2007Review
- Prevalence of ColE1-like plasmids and colicin K production among uropathogenic Escherichia coli strains and quantification of inhibitory activity of colicin K.Applied and environmental microbiology · 2007Article
- Sublethal concentrations of ciprofloxacin induce bacteriocin synthesis in Escherichia coli.Antimicrobial agents and chemotherapy · 2005Article
- A cka-gfp transcriptional fusion reveals that the colicin K activity gene is induced in only 3 percent of the population.Journal of bacteriology · 2003Article
- Growth-phase-dependent expression of the cyclopeptide antibiotic microcin J25.Journal of bacteriology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colicin-producing strains occur frequently in natural populations of Escherichia coli, and colicinogenicity seems to provide a competitive advantage in the natural habitat. A cka-lacZ fusion was used to study the regulation of expression of the colicin K structural gene. Expression is growth phase dependent, with high activity in the late stationary phase. Nutrient depletion induces the expression of cka due to an increase in ppGpp. Temperature is a strong signal for cka expression, since only basal-level activity was detected at 22 degrees C. Mitomycin C induction demonstrates that cka expression is regulated to a lesser extent by the SOS response independently of ppGpp. Increased osmolarity induces a partial increase, while the global regulator integration host factor inhibits expression in the late stationary phase. Induction of cka was demonstrated to be independent of the cyclic AMP-Crp complex, carbon source, RpoS, Lrp, H-NS, pH, and short-chain fatty acids. In contrast to colicin E1, cka expression is independent of catabolite repression and is partially affected by anaerobiosis only upon SOS induction. These results indicate that while different colicins are expressed in response to some common signals such as nutrient depletion, the expression of individual colicins could be further influenced by specific environmental cues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.