ArticleProceedings of the National Academy of Sciences of the United States of America1999
Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 126 citations in OpenAlex.
- Cooperative interactions between neurotrophin receptors and CXCR4 regulate macrophage phenotype and susceptibility to activation by HIV.Journal of neurovirology · 2024Article
- Review
- Neurotrophins: Neuroimmune Interactions in Human Atopic Diseases.International journal of molecular sciences · 2023Review
- Review
- Neurotrophin Signaling Impairment by Viral Infections in the Central Nervous System.International journal of molecular sciences · 2022Review
- Brain-Derived Neurotrophic Factor Suppressed Proinflammatory Cytokines Secretion and Enhanced MicroRNA(miR)-3168 Expression in Macrophages.International journal of molecular sciences · 2022Article
- Different Patterns of HIV-1 Replication in MACROPHAGES is Led by Co-Receptor Usage.Medicina (Kaunas, Lithuania) · 2019Article
- Article
- Neuroendocrine Control of Macrophage Development and Function.Frontiers in immunology · 2018Review
- Nanoparticles increase human bronchial epithelial cell susceptibility to respiratory syncytial virus infection via nerve growth factor-induced autophagy.Physiological reports · 2017Article
- Review
- The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Opposing Effects of NGF and proNGF on HIV Induced Macrophage Activation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Article
- Differential regulation of macrophage phenotype by mature and pro-nerve growth factor.Journal of neuroimmunology · 2015Article
- Dynamic nature of the p75 neurotrophin receptor in response to injury and disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2014Review
- Understanding HIV compartments and reservoirs.Current HIV/AIDS reports · 2014Review
- Respiratory syncytial virus and asthma: speed-dating or long-term relationship?Current opinion in pediatrics · 2013Review
- Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.Human genetics · 2012Article
- MicroRNA-221 modulates RSV replication in human bronchial epithelium by targeting NGF expression.PloS one · 2012Article
- HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sites.HIV/AIDS (Auckland, N.Z.) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve growth factor (NGF) is a neurotrophin with the ability to exert specific effects on cells of the immune system. Human monocytes/macrophages (M/M) infected in vitro with HIV type 1 (HIV-1) are able to produce substantial levels of NGF that are associated with enhanced expression of the high-affinity NGF receptor (p140 trkA) on the M/M surface. Treatment of HIV-infected human M/M with anti-NGF Ab blocking the biological activity of NGF leads to a marked decrease of the expression of p140 trkA high-affinity receptor, a concomitant increased expression of p75(NTR) low-affinity receptor for NGF, and the occurrence of apoptotic death of M/M. Taken together, these findings suggest a role for NGF as an autocrine survival factor that rescues human M/M from the cytopathic effect caused by HIV infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.