ArticleProceedings of the National Academy of Sciences of the United States of America1999
Promoter-specific hypoacetylation of X-inactivated genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Multifaceted role of CTCF in X-chromosome inactivation.Chromosoma · 2024Review
- Escape from X inactivation varies in mouse tissues.PLoS genetics · 2015Article
- Genetic architecture of skewed X inactivation in the laboratory mouse.PLoS genetics · 2013Article
- Study of methylation of histone H3 lysine 9 and H3 lysine 27 during X chromosome inactivation in three types of cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Finding a balance: how diverse dosage compensation strategies modify histone h4 to regulate transcription.Genetics research international · 2012Article
- Synergism between DNA methylation and macroH2A1 occupancy in epigenetic silencing of the tumor suppressor gene p16(CDKN2A).Nucleic acids research · 2011Article
- Article
- X chromosome-wide analyses of genomic DNA methylation states and gene expression in male and female neutrophils.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells.The American journal of pathology · 2009Article
- ATRX marks the inactive X chromosome (Xi) in somatic cells and during imprinted X chromosome inactivation in trophoblast stem cells.Chromosoma · 2009Article
- Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation.Human genetics · 2006Article
- Epigenetic predisposition to expression of TIMP1 from the human inactive X chromosome.BMC genetics · 2005Article
- Normal histone modifications on the inactive X chromosome in ICF and Rett syndrome cells: implications for methyl-CpG binding proteins.BMC biology · 2004Article
- Heterochromatin on the inactive X chromosome delays replication timing without affecting origin usage.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genes.Molecular and cellular biology · 2003Article
- Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells.Nucleic acids research · 2002Article
- Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome.The Journal of cell biology · 2002Article
- Identification and punctate nuclear localization of a novel noncoding RNA, Ks-1, from the honeybee brain.RNA (New York, N.Y.) · 2002Article
- Allele-specific underacetylation of histone H4 downstream from promoters is associated with X-inactivation in human cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2002Article
- Histone variant macroH2A contains two distinct macrochromatin domains capable of directing macroH2A to the inactive X chromosome.Nucleic acids research · 2001Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The histone H4 acetylation status of the active X (Xa) and inactive X (Xi) chromosomes was investigated at the level of individual genes. A moderate level of acetylation was observed along the lengths of genes on both the Xi and Xa, regardless of their X inactivation status. However, this moderate level of acetylation was modified specifically in promoter regions. Transcriptionally active genes showed elevated levels of acetylation at their promoters on both the Xi and Xa. In contrast, promoters of X-inactivated genes were markedly hypoacetylated, which coincided with the methylation of adjacent CG dinucleotides. This promoter-specific hypoacetylation may be a key component of an X inactivation machinery that operates at the level of individual genes.
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