ReviewProceedings of the National Academy of Sciences of the United States of America1999
Chromatin modification by DNA tracking.
Review in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 90 citations in OpenAlex.
- Saccharomyces cerevisiae malate dehydrogenase Mdh1p lacking mitochondrial targeting signal can be re-localized to peroxisomes.Biology open · 2025Article
- Enhancer selectivity in space and time: from enhancer-promoter interactions to promoter activation.Nature reviews. Molecular cell biology · 2024Review
- eRNA co-expression network uncovers TF dependency and convergent cooperativity.Scientific reports · 2023Article
- Enhancer Function in the 3D Genome.Genes · 2023Review
- Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure.Epigenetics & chromatin · 2017Article
- Review
- The landscape of RNA polymerase II transcription initiation in C. elegans reveals promoter and enhancer architectures.Genome research · 2013Article
- Structure and Mechanisms of SF1 DNA Helicases.Advances in experimental medicine and biology · 2013Article
- Both the constitutive cauliflower mosaic virus 35S and tissue-specific AGAMOUS enhancers activate transcription autonomously in Arabidopsis thaliana.Plant molecular biology · 2010Article
- Article
- Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III.PLoS genetics · 2007Article
- Review
- Gene and genon concept: coding versus regulation. A conceptual and information-theoretic analysis of genetic storage and expression in the light of modern molecular biology.Theory in biosciences = Theorie in den Biowissenschaften · 2007Article
- Transcription through chromatin by RNA polymerase II: histone displacement and exchange.Mutation research · 2007Review
- A facilitated tracking and transcription mechanism of long-range enhancer function.Nucleic acids research · 2007Article
- Transcription-coupled deposition of histone modifications during MHC class II gene activation.Nucleic acids research · 2007Article
- Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters.Nature immunology · 2005Article
- Multiple links between transcription and splicing.RNA (New York, N.Y.) · 2004Review
- Developmental stage differences in chromatin subdomains of the beta-globin locus.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- An insulator blocks spreading of histone acetylation and interferes with RNA polymerase II transfer between an enhancer and gene.Nucleic acids research · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In general, the transcriptional competence of a chromatin domain is correlated with increased sensitivity to DNase I cleavage. A recent observation that actively transcribing RNA polymerase II piggybacks a histone acetyltranferase activity [Wittschieben, B., Otero, G., de Bizemont, T., Fellows, J., Erdjument-Bromage, H., Ohba, R., Li, Y., Allis, C. D., Tempst, P. & Svejstrup, J. Q. (1999) Mol. Cell 4, 123-128] implies that the state of histone acetylation, and hence the ability of chromatin to fold, can be altered by a processive mechanism. In this article, it is proposed that tracking-mediated chromatin modification could create and/or maintain an open configuration in a complete chromatin domain including both intra- and extragenic regions. This mechanism suggests a putative functional role for the extragenic transcription observed at the beta-globin and other loci in vertebrate cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.