ArticleInfection and immunity1999
Attenuated expression of the mga virulence regulon in an M serotype 50 mouse-virulent group A streptococcal strain.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- ModelingFrontiers in cellular and infection microbiology · 2019Review
- Article
- Role of Mga in group A streptococcal infection at the skin epithelium.Microbial pathogenesis · 2008Article
- Identification of residues responsible for the defective virulence gene regulator Mga produced by a natural mutant of Streptococcus pyogenes.Journal of bacteriology · 2005Article
- Restoration of Mga function to a Streptococcus pyogenes strain (M Type 50) that is virulent in mice.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The attenuated expression of virulence genes found in a group A streptococcal strain that is naturally pathogenic for mice was postulated to result from a defect in the strain's multigene regulator, Mga. The sequence of the mga gene reveals three amino acid changes in the gene product that might affect protein function. The defect in the mga gene was complemented by providing either the closely similar mga4 allele or a more divergent mga1 allele in trans. Complementation increased the amount of emm50 transcript and the quantity of surface-extractable M protein, restoring virulence function.
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