ArticleInfection and immunity1999
Calgranulin C has filariacidal and filariastatic activity.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
- Capping motifs in antimicrobial peptides and their relevance for improved biological activities.Frontiers in chemistry · 2024Review
- The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions.Molecules (Basel, Switzerland) · 2023Review
- Dynamic regulation of Zn(II) sequestration by calgranulin C.Protein science : a publication of the Protein Society · 2022Article
- The impact of metal availability on immune function during infection.Trends in endocrinology and metabolism: TEM · 2021Review
- Ca(II) and Zn(II) Cooperate To Modulate the Structure and Self-Assembly of S100A12.Biochemistry · 2019Article
- Antimicrobial action of calprotectin that does not involve metal withholding.Metallomics : integrated biometal science · 2018Article
- A multiomics analysis of S100 protein family in breast cancer.Oncotarget · 2018Article
- Effect of selected gastrointestinal parasites and viral agents on fecal S100A12 concentrations in puppies as a potential comparative model.Parasites & vectors · 2018Article
- Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins.Biochemistry · 2018Article
- S100/RAGE-Mediated Inflammation and Modified Cholesterol Lipoproteins as Mediators of Osteoblastic Differentiation of Vascular Smooth Muscle Cells.Frontiers in cardiovascular medicine · 2018Review
- Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis.Scientific reports · 2016Article
- Stage-specific Proteomes from Onchocerca ochengi, Sister Species of the Human River Blindness Parasite, Uncover Adaptations to a Nodular Lifestyle.Molecular & cellular proteomics : MCP · 2016Article
- S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages.PLoS pathogens · 2016Article
- [Translational research in pediatric rheumatology. Current research approaches to the innate immune system].Zeitschrift fur Rheumatologie · 2016Review
- Calcium Ions Tune the Zinc-Sequestering Properties and Antimicrobial Activity of Human S100A12.Chemical science · 2016Article
- Keratin and S100 calcium-binding proteins are major constituents of the bovine teat canal lining.Veterinary research · 2015Article
- Potential effects of calcium binding protein S100A12 on severity evaluation and curative effect of severe acute pancreatitis.Inflammation · 2015Article
- Human filarial Wolbachia lipopeptide directly activates human neutrophils in vitro.Parasite immunology · 2014Article
- Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis.Frontiers in cellular and infection microbiology · 2014Review
- Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The calgranulins are a family of calcium- and zinc-binding proteins produced by neutrophils, monocytes, and other cells. Calgranulins are released during inflammatory responses and have antimicrobial activity. Recently, one of the calgranulins, human calgranulin C (CaGC), has been implicated as an important component of the host responses that limit the parasite burden during filarial nematode infections. The goal of this work was to test the hypothesis that human CaGC has biologic activity against filarial parasites. Brugia malayi microfilariae and adults were exposed in vitro to 0.75 to 100 nM recombinant human CaGC. Recombinant CaGC affected adult and larval parasites in a dose-dependent fashion. Microfilariae were more sensitive to the action of CaGC than were adult parasites. At high levels, CaGC was both macrofilariacidal and microfilariacidal. At lower levels, the percentage of parasites killed was dependent on the level of CaGC in the culture system. The larvae not killed had limited motility. The filariastatic effect of low-level CaGC was reversed when the CaGC was removed from the culture system. Immunohistochemical analysis demonstrated that human CaGC accumulated in the cells of the hypodermis-lateral chord of adult and larval parasites. The antifilarial activity of CaGC was not due to the sequestration of zinc. Thus, the cellular and molecular mechanisms that result in the production and release of CaGC in humans may play a key role in the regulation of filarial parasite numbers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.