ArticleMolecular and cellular biochemistry1999
Nitric oxide inhibits wounds collagen synthesis.
Article in Molecular and cellular biochemistry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 74 citations in OpenAlex.
- Optogenetic engineered umbilical cord MSC-derived exosomes for remodeling of the immune microenvironment in diabetic wounds and the promotion of tissue repair.Journal of nanobiotechnology · 2023Article
- Histological assessment of the local effect of different concentrations of aminoguanidine hydrochloride on bone healing in rats.Dental research journal · 2021Article
- Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress.Reproductive sciences (Thousand Oaks, Calif.) · 2014Review
- S-nitrosoglutathione accelerates recovery from 5-fluorouracil-induced oral mucositis.PloS one · 2014Article
- The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants.Biomaterials · 2012Article
- Postoperative adhesion development following cesarean and open intra-abdominal gynecological operations: a review.Reproductive sciences (Thousand Oaks, Calif.) · 2011Review
- The use of aminoguanidine, a selective inducible nitric oxide synthase inhibitor, to evaluate the role of nitric oxide on periapical healing.Dental research journal · 2011Article
- The role of nitric oxide during healing of trauma to the skeletal muscle.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Competitive formation of N-diazeniumdiolates and N-nitrosamines via anaerobic reactions of polyamines with nitric oxide.Organic letters · 2009Article
- Inflammatory levels of nitric oxide inhibit airway epithelial cell migration by inhibition of the kinase ERK1/2 and activation of hypoxia-inducible factor-1 alpha.The Journal of biological chemistry · 2008Article
- Article
- Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Implications of nitric oxide synthase isoforms in the pathophysiology of Peyronie's disease.International journal of impotence research · 2002Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is a messenger molecule which regulates many physiological functions like immunity, vascular tone and serves as a neurotransmitter. Although it is known to participate in healing process, its role in collagen synthesis is not clear. Therefore, the present investigation was done to study the role of NO in wound collagen synthesis. Rats received full thickness, circular (8 mm), transdermal wounds which were treated with NO releaser, sodium nitroprusside (SNP, 0.001 100 microM) topically for 5 days. Wound collagen content estimated in terms of hydroxyproline (HP) and confirmed histochemically was decreased significantly by all SNP doses. L-Arginine, a substrate for nitric oxide synthase (NOS) when applied topically decreased collagen content of the wounded tissues. N-Nitro-L-arginine methyl ester (L-NAME), a competitive inhibitor of NOS, increased wound collagen content significantly as compared to untreated and SNP treated animal wounds when administered intraperitoneally at the doses 3, 10 and 30 mg/kg. Furthermore, histological findings also demonstrated laying down of thick collagen bundles and proliferation of fibroblasts together with prominent angiogenesis in L-NAME treated wound tissues as compared to untreated and SNP treated tissues. N-nitro-D-arginine methyl ester, an inactive isomer, was found to have no effect on wound collagen levels. When L-arginine was administered in L-NAME pretreated rats, it significantly elevated wound HP content. The results indicate that NO plays an important role in regulating the collagen biosynthesis in skin model of a healing wound.
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