ArticleMolecular and cellular biology1999
Dual role of the mitochondrial chaperone Mdj1p in inheritance of mitochondrial DNA in yeast.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- The mitochondrial DnaJA protein LMA1 regulates reactive oxygen species homeostasis and anthocyanin biosynthesis inPlant diversity · 2026Article
- Functions of J-domain proteins in mitochondrial protein biogenesis.Protein science : a publication of the Protein Society · 2026Review
- Review
- Identification of novel genes responsible for salt tolerance by transposon mutagenesis in Saccharomyces cerevisiae.Journal of industrial microbiology & biotechnology · 2015Article
- Article
- DNA polymerase γ and disease: what we have learned from yeast.Frontiers in genetics · 2015Review
- Nucleoid localization of Hsp40 Mdj1 is important for its function in maintenance of mitochondrial DNA.Biochimica et biophysica acta · 2013Article
- Loss of mitochondrial DNA under genotoxic stress conditions in the absence of the yeast DNA helicase Pif1p occurs independently of the DNA helicase Rrm3p.Molecular genetics and genomics : MGG · 2009Article
- Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast.Molecular biology of the cell · 2003Article
- Mitochondrial GFA2 is required for synergid cell death in Arabidopsis.The Plant cell · 2002Article
- Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome.Molecular and cellular biology · 2000Article
- In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mdj1p, a homolog of the bacterial DnaJ chaperone protein, plays an essential role in the biogenesis of functional mitochondria in the yeast Saccharomyces cerevisiae. We analyzed the role of Mdj1p in the inheritance of mitochondrial DNA (mtDNA). Mitochondrial genomes were rapidly lost in a temperature-sensitive mdj1 mutant under nonpermissive conditions. The activity of mtDNA polymerase was severely reduced in the absence of functional Mdj1p at a nonpermissive temperature, demonstrating the dependence of the enzyme on Mdj1p. At a permissive temperature, the activity of mtDNA polymerase was not affected by the absence of Mdj1p. However, under these conditions, intact [rho(+)] genomes were rapidly converted to nonfunctional [rho(-)] genomes which were stably propagated in an mdj1 deletion strain. We propose that mtDNA polymerase depends on Mdj1p as a chaperone in order to acquire and/or maintain an active conformation at an elevated temperature. In addition, Mdj1p is required for the inheritance of intact mitochondrial genomes at a temperature supporting optimal growth; this second function appears to be unrelated to the function of Mdj1p in maintaining mtDNA polymerase activity.
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