ArticleBMJ (Clinical research ed.)1999
Association between birth weight and adult blood pressure in twins: historical cohort study.
Article in BMJ (Clinical research ed.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 155 citations in OpenAlex.
- Twin gestation and the burden of adult cardio-renal disease.Pediatric nephrology (Berlin, Germany) · 2020Review
- Genetic, maternal and placental factors in the association between birth weight and physical fitness: a longitudinal twin study.PloS one · 2013Article
- Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.PLoS genetics · 2012Article
- Beyond genome-wide association studies: new strategies for identifying genetic determinants of hypertension.Current hypertension reports · 2011Review
- Article
- Birth weight effects on children's mental, motor, and physical development: evidence from twins data.Maternal and child health journal · 2009Article
- Vascular nitric oxide and superoxide anion contribute to sex-specific programmed cardiovascular physiology in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Hypotheses on the fetal origins of adult diseases: contributions of epidemiological studies.European journal of epidemiology · 2006Review
- Genetic and environmental influences on birthweight in a sample of Korean twins.Journal of Korean medical science · 2005Article
- Do genetic factors contribute to the association between birth weight and blood pressure?Journal of epidemiology and community health · 2001Article
- Dermatoglyphic patterns, very low birth weight, and blood pressure in adolescence.Archives of disease in childhood. Fetal and neonatal edition · 2001Article
- Limitations of models used to examine the influence of nutrition during pregnancy and adult disease.Archives of disease in childhood · 2000Review
- Twins and fetal programming of blood pressure. Questioning the role of genes and maternal nutrition.BMJ (Clinical research ed.) · 1999Article
- The life-course association of birth-weight genes with self-rated health.Biodemography and social biologyArticle
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5 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate the associations in twins between within pair differences in birth weight and subsequent blood pressures as adults thereby removing the impact of potential parental confounding variables.
designHistorical cohort study.
settingSt Thomas's UK adult twin register, June 1992 to September 1995.
participants492 pairs of female twins (mean age 54 years).
main outcome measuresMean within pair differences in adult blood pressure in each of four strata of within pair differences in birth weight (0, 1-500 g, 501-1000 g, >1000 g). Differences in blood pressure were analysed before and after adjustment for potential confounders between adult twins, after exclusion of those twin pairs including at least one twin taking antihypertensive drugs, and by zygosity.
resultsReported mean birth weights of heavier and lighter twins were 2.51 (SD 0.61) v 2.12 (0.59) kg respectively. A graded inverse relation between strata of within pair differences in birth weight and differences in adult blood pressure was apparent, with an adjusted blood pressure range of 8.7/5.1 mm Hg across the four strata (test for trend: systolic, P=0.05; diastolic, P=0.09). After excluding those women taking antihypertensive drugs the significance of the association was similar (systolic, P=0.04; diastolic, P=0.10). When differences in blood pressure were stratified for zygosity similar but non-significant trends were apparent.
conclusionIt would seem that birth weight is inversely associated with adult blood pressure and that this association is independent of parental confounding variables probably including, in view of the findings in monozygotic twins, genetic factors. The observed blood pressure differences are likely to result from retarded intrauterine growth due to placental dysfunction rather than inadequate maternal nutrition.
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