ArticleBMJ (Clinical research ed.)1999
Within pair association between birth weight and blood pressure at age 8 in twins from a cohort study.
Article in BMJ (Clinical research ed.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 113 citations in OpenAlex.
- Twin gestation and the burden of adult cardio-renal disease.Pediatric nephrology (Berlin, Germany) · 2020Review
- Optimal design strategies for sibling studies with binary exposures.The international journal of biostatistics · 2014Article
- Is fetal macrosomia related to blood pressure among adolescents? A birth cohort study in China.Journal of human hypertension · 2013Article
- Birth weight effects on children's mental, motor, and physical development: evidence from twins data.Maternal and child health journal · 2009Article
- Twins eye study in Tasmania (TEST): rationale and methodology to recruit and examine twins.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2009Article
- Effects of twin pregnancy and periconceptional undernutrition on maternal metabolism, fetal growth and glucose-insulin axis function in ovine pregnancy.The Journal of physiology · 2008Article
- Hypotheses on the fetal origins of adult diseases: contributions of epidemiological studies.European journal of epidemiology · 2006Review
- Genetic and environmental influences on birthweight in a sample of Korean twins.Journal of Korean medical science · 2005Article
- Do genetic factors contribute to the association between birth weight and blood pressure?Journal of epidemiology and community health · 2001Article
- Review
- Dermatoglyphic patterns, very low birth weight, and blood pressure in adolescence.Archives of disease in childhood. Fetal and neonatal edition · 2001Article
- Limitations of models used to examine the influence of nutrition during pregnancy and adult disease.Archives of disease in childhood · 2000Review
- Twins and fetal programming of blood pressure. Questioning the role of genes and maternal nutrition.BMJ (Clinical research ed.) · 1999Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo study the association between birth weight and blood pressure in children from multiple pregnancies (multiplets), mostly twins, to determine whether maternal or genetic factors are responsible for the association.
designCohort study.
settingSouthern Tasmania. SUBJECTS: 888 children including 104 multiplets (32 monozygotic, 72 dizygotic).
main outcome measureSystolic blood pressure (mm Hg).
resultsBlood pressure decreased with birth weight and increased with current body mass. After adjustment for age and body mass, systolic blood pressure changed by -1.94 mm Hg (95% confidence interval -2.89 to -0.98) per 1 kg increase in birth weight of singletons. For multiplets, blood pressure changed by -7.0 mm Hg (-10.1 to -3.9) for each 1 kg increase in birth weight. This was little altered in within pair analyses (-5.3, -13.8 to 3.2) and was similar for both monozygotic (-6.5, -22.5 to 9.4) and dizygotic (-4.9, -15.8 to 6.0) pairs.
conclusionBecause the association between birth weight and blood pressure was largely unchanged in within pair analyses, exposures originating in the mother (such as nutritional status) cannot be wholly responsible. The association also remained within monozygotic pairs, suggesting that genetic predisposition is not wholly responsible either. The principal causal pathway must concern mechanisms within the fetoplacental unit. The stronger association in multiplets suggests that factors adversely influencing both blood pressure and birth weight are more prevalent in multiple pregnancies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.