ArticleJournal of clinical microbiology1999
Transmission dynamics of tuberculosis in a high-incidence country: prospective analysis by PCR DNA fingerprinting.
Article in Journal of clinical microbiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Do Incarcerated Populations Serve as a Reservoir for Tuberculosis in South Africa?The American journal of tropical medicine and hygiene · 2018Article
- Setting priorities in health research using the model proposed by the World Health Organization: development of a quantitative methodology using tuberculosis in South Africa as a worked example.Health research policy and systems · 2016Article
- What has Karonga taught us? Tuberculosis studied over three decades.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2009Article
- First molecular epidemiology study of Mycobacterium tuberculosis in Burkina Faso.Journal of clinical microbiology · 2007Article
- Fast ligation-mediated PCR, a fast and reliable method for IS6110-based typing of Mycobacterium tuberculosis complex.Journal of clinical microbiology · 2005Article
- Genetic biodiversity of Mycobacterium tuberculosis complex strains from patients with pulmonary tuberculosis in Cameroon.Journal of clinical microbiology · 2003Article
- Molecular epidemiology of tuberculosis in a rural area of high prevalence in South India: implications for disease control and prevention.Journal of clinical microbiology · 2002Article
- Mycobacterium africanum subtype II is associated with two distinct genotypes and is a major cause of human tuberculosis in Kampala, Uganda.Journal of clinical microbiology · 2002Article
- Molecular epidemiology and drug resistance of Mycobacterium tuberculosis isolates from Ethiopian pulmonary tuberculosis patients with and without human immunodeficiency virus infection.Journal of clinical microbiology · 2002Article
- Molecular epidemiology of Mycobacterium tuberculosis in Norway.Journal of clinical microbiology · 2001Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have prospectively analyzed the DNA fingerprints of Mycobacterium tuberculosis strains from a random sample of patients with newly diagnosed tuberculosis in Windhoek, Namibia. Strains from 263 smear-positive patients in whom tuberculosis was diagnosed during 1 year were evaluated, and the results were correlated with selected epidemiological and clinical data. A total of 163 different IS6110 fingerprint patterns were observed among the 263 isolates. Isolates from a high percentage of patients (47%) were found in 29 separate clusters, with a cluster defined as isolates with 100% matching patterns. The largest cluster included isolates from 39 patients. One predominant strain of M. tuberculosis caused 15% of cases of smear-positive pulmonary tuberculosis in Windhoek. That strain was also prevalent in the north of the country, suggesting that in contrast to other African countries with isolates with high levels of diversity in their DNA fingerprint patterns, only a restricted number of different strains significantly contribute to the tuberculosis problem in Namibia.
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