ArticleJournal of clinical microbiology1999
Detection of fluconazole-resistant Candida strains by a disc diffusion screening test.
Article in Journal of clinical microbiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Fluconazole resistance amongFrontiers in fungal biology · 2025Article
- Can We Improve Antifungal Susceptibility Testing?Frontiers in cellular and infection microbiology · 2021Review
- Medium-Chain Fatty Acids Released from Polymeric Electrospun Patches InhibitACS biomaterials science & engineering · 2020Article
- Susceptibility tests of oropharyngeal Candida albicans from egyptian patients to fluconazole determined by three methods.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2012Article
- Comparison of Neo-Sensitabs tablet diffusion assay with CLSI broth microdilution M38-A and disk diffusion methods for testing susceptibility of filamentous fungi with amphotericin B, caspofungin, itraconazole, posaconazole, and voriconazole.Journal of clinical microbiology · 2008Article
- Correlation of Neo-Sensitabs tablet diffusion assay results on three different agar media with CLSI broth microdilution M27-A2 and disk diffusion M44-A results for testing susceptibilities of Candida spp. and Cryptococcus neoformans to amphotericin B, caspofungin, fluconazole, itraconazole, and voriconazole.Journal of clinical microbiology · 2007Article
- Quality control limits for posaconazole disk susceptibility tests on Mueller-Hinton agar with glucose and methylene blue.Journal of clinical microbiology · 2007Article
- Species diversity of yeast in oral colonization of insulin-treated diabetes mellitus patients.Mycopathologia · 2006Article
- Quality control limits for fluconazole disk susceptibility tests on Mueller-Hinton agar with glucose and methylene blue.Journal of clinical microbiology · 2003Article
- Comparison of results obtained by testing with three different agar media and by the NCCLS M27-A method for in vitro testing of fluconazole against Candida spp.Journal of clinical microbiology · 2003Article
- Detection of fluconazole-resistant isolates of Candida glabrata by using an agar screen assay.Journal of clinical microbiology · 2003Article
- Susceptibility testing of fluconazole by the NCCLS broth macrodilution method, E-test, and disk diffusion for application in the routine laboratory.Journal of clinical microbiology · 2002Article
- Antifungal susceptibility testing: practical aspects and current challenges.Clinical microbiology reviews · 2001Review
- Fluconazole and voriconazole multidisk testing of Candida species for disk test calibration and MIC estimation.Journal of clinical microbiology · 2001Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A commercial disc diffusion test has been evaluated as a screening method for the detection of Candida species with decreased susceptibility to fluconazole. A total of 1,407 Candida strains of different species were tested, and the results were compared with the MIC results. The recently published National Committee for Clinical Laboratory Standards breakpoint criteria have been used. Isolates were classified as susceptible if the MIC for the isolates was </=8 microg/ml, susceptible-dose dependent (S-DD) if the MIC was 16 to 32 microg/ml, and resistant if the MIC was >/=64 microg/ml. All 77 resistant strains and 121 of 122 S-DD strains had fluconazole zone diameters of </=21 mm, and most of the strains (91%) had zone diameters of </=15 mm. It was not possible to distinguish between resistant and S-DD strains by the disc test. Among a total of 1,208 strains found to be susceptible by the microdilution method, 49 (4. 1%) yielded fluconazole zone sizes of </=21 mm and would have been misclassified as resistant or S-DD strains on the basis of the disc test. For the majority (86%) of these 49 strains the fluconazole MIC was 8 microg/ml. The fluconazole disc test is recommended as a simple and reliable screening test for the detection of Candida strains with decreased susceptibility to fluconazole. Fluconazole MICs should be determined for strains found to be resistant by the disc test. The reason for confirmatory testing is twofold: to determine if isolates are resistant or S-DD, since the disc test does not make this distinction, and to identify fluconazole-susceptible strains that are found to be falsely resistant by the fluconazole disc test.
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