ReviewExperimental physiology1999
Membrane oestrogen receptors on rat pituitary tumour cells: immuno-identification and responses to oestradiol and xenoestrogens.
Review in Experimental physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 93 citations in OpenAlex.
- A Review on Sex Steroid Hormone Estrogen Receptors in Mammals and Fish.International journal of endocrinology · 2020Review
- Methylmercury promotes breast cancer cell proliferation.Toxicology reports · 2018Article
- Non-genomic effects of xenoestrogen mixtures.International journal of environmental research and public health · 2012Review
- Endocrine disruption via estrogen receptors that participate in nongenomic signaling pathways.The Journal of steroid biochemistry and molecular biology · 2011Review
- ER-α36, a novel variant of ER-α, mediates estrogen-stimulated proliferation of endometrial carcinoma cells via the PKCδ/ERK pathway.PloS one · 2010Article
- Combinations of physiologic estrogens with xenoestrogens alter calcium and kinase responses, prolactin release, and membrane estrogen receptor trafficking in rat pituitary cells.Environmental health : a global access science source · 2010Article
- Estrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells.Cancer research · 2010Article
- Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons.Molecular endocrinology (Baltimore, Md.) · 2009Article
- G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells.Environmental health perspectives · 2008Article
- Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Adaptation to estradiol deprivation causes up-regulation of growth factor pathways and hypersensitivity to estradiol in breast cancer cells.Advances in experimental medicine and biology · 2008Review
- Caveolin proteins are essential for distinct effects of membrane estrogen receptors in neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Article
- Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators.Environmental health perspectives · 2007Article
- Estradiol activates group I and II metabotropic glutamate receptor signaling, leading to opposing influences on cAMP response element-binding protein.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-alpha-mediated Ca2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells.Environmental health perspectives · 2005Article
- Disentangling the molecular mechanisms of action of endogenous and environmental estrogens.Pflugers Archiv : European journal of physiology · 2005Review
- Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways.Environmental health perspectives · 2004Article
- The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Regulation of the membrane estrogen receptor-alpha: role of cell density, serum, cell passage number, and estradiol.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2002Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Our laboratory has identified plasma membrane oestrogen receptors on a GH3/B6 rat pituitary tumour cell line and several sublines which produce rapid (within minutes), non-genomic responses to oestrogens. Oestrogen receptors have been identified by their binding to nine different antibodies (Abs) which together recognize at least seven epitopes on the oestrogen receptor-alpha. GH3/B6/F10 cells, a membrane oestrogen receptor-enriched subline, elevate intracellular calcium levels in response to 10 nM oestradiol. Prolactin release in these cells is triggered by both 1 pM and 1 nM oestradiol and diethylstilbestrol (DES). A membrane oestrogen receptor-alpha immunocytochemical signal rapidly disappears (at 3 min) and reappears (at 12-15 min) when 1 nM oestradiol, 10 nM diethylstilbestrol, or 10 nM nonylphenol is applied to the cells. This suggests that both oestrogens and xenoestrogens can utilize this alternative pathway for oestrogenic action. Xenoestrogens, which have so far shown weak effects in genomic assay systems, should now be retested for activity in eliciting membrane-initiated oestrogenic responses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.