ArticleMolecular biology of the cell1999
Box H and box ACA are nucleolar localization elements of U17 small nucleolar RNA.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- SnoRNAs: Exploring Their Implication in Human Diseases.International journal of molecular sciences · 2024Review
- Discovery of 17 conserved structural RNAs in fungi.Nucleic acids research · 2021Article
- snR30/U17 Small Nucleolar Ribonucleoprotein: A Critical Player during Ribosome Biogenesis.Cells · 2020Review
- Assembly and trafficking of box C/D and H/ACA snoRNPs.RNA biology · 2017Review
- The path from student to mentor and from chromosomes to replication to genomics.Molecular biology of the cell · 2016Article
- RNA pseudouridylation: new insights into an old modification.Trends in biochemical sciences · 2013Review
- Telomerase trafficking and assembly in Xenopus oocytes.Journal of cell science · 2010Article
- Insight into the Protein Components of the Box H/ACA RNP.Current proteomics · 2008Article
- Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae.Molecular and cellular biology · 2008Article
- Genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Leishmania major indicates conservation among trypanosomatids in the repertoire and in their rRNA targets.Eukaryotic cell · 2007Article
- Human box H/ACA pseudouridylation guide RNA machinery.Molecular and cellular biology · 2004Article
- Differential subnuclear localization of RNA strands of opposite polarity derived from an autonomously replicating viroid.The Plant cell · 2003Article
- U4 snRNA nucleolar localization requires the NHPX/15.5-kD protein binding site but not Sm protein or U6 snRNA association.The Journal of cell biology · 2003Article
- A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs.The EMBO journal · 2003Article
- Structural and sequence evolution of U17 small nucleolar RNA (snoRNA) and its phylogenetic congruence in chelonians.Journal of molecular evolution · 2003Article
- Naf1p, an essential nucleoplasmic factor specifically required for accumulation of box H/ACA small nucleolar RNPs.Molecular and cellular biology · 2002Article
- All small nuclear RNAs (snRNAs) of the [U4/U6.U5] Tri-snRNP localize to nucleoli; Identification of the nucleolar localization element of U6 snRNA.Molecular biology of the cell · 2002Article
- Small nucleolar RNAs: versatile trans-acting molecules of ancient evolutionary origin.Gene expression · 2002Review
- Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs.The EMBO journal · 2001Review
- Fluorescent RNA cytochemistry: tracking gene transcripts in living cells.Nucleic acids research · 2001Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The nucleolar localization elements (NoLEs) of U17 small nucleolar RNA (snoRNA), which is essential for rRNA processing and belongs to the box H/ACA snoRNA family, were analyzed by fluorescence microscopy. Injection of mutant U17 transcripts into Xenopus laevis oocyte nuclei revealed that deletion of stems 1, 2, and 4 of U17 snoRNA reduced but did not prevent nucleolar localization. The deletion of stem 3 had no adverse effect. Therefore, the hairpins of the hairpin-hinge-hairpin-tail structure formed by these stems are not absolutely critical for nucleolar localization of U17, nor are sequences within stems 1, 3, and 4, which may tether U17 to the rRNA precursor by base pairing. In contrast, box H and box ACA are major NoLEs; their combined substitution or deletion abolished nucleolar localization of U17 snoRNA. Mutation of just box H or just the box ACA region alone did not fully abolish the nucleolar localization of U17. This indicates that the NoLEs of the box H/ACA snoRNA family function differently from the bipartite NoLEs (conserved boxes C and D) of box C/D snoRNAs, where mutation of either box alone prevents nucleolar localization.
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