ArticleMolecular biology of the cell1999
Uptake and intracellular transport of acidic fibroblast growth factor: evidence for free and cytoskeleton-anchored fibroblast growth factor receptors.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Sprouty2 Regulates Endocytosis and Degradation of Fibroblast Growth Factor Receptor 1 in Glioblastoma Cells.Cells · 2024Article
- Article
- NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice.Brain : a journal of neurology · 2018Article
- Regulation of Caveolin-1 and Junction Proteins by bFGF Contributes to the Integrity of Blood-Spinal Cord Barrier and Functional Recovery.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Article
- Article
- FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway.PloS one · 2014Article
- Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8.Journal of cell science · 2013Article
- Sorting of the FGF receptor 1 in a human glioma cell line.Histochemistry and cell biology · 2013Article
- Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis.Science signaling · 2012Article
- Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis.Molecular biology of the cell · 2008Article
- Lipid rafts serve as a signaling platform for nicotinic acetylcholine receptor clustering.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1.Molecular biology of the cell · 2005Article
- BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation.The Journal of cell biology · 2004Article
- Translocation of FGF-1 and FGF-2 across vesicular membranes occurs during G1-phase by a common mechanism.Molecular biology of the cell · 2004Article
- Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1.The Biochemical journal · 2003Article
- Syndecan-4: dispensable or indispensable?Glycoconjugate journalReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocytic uptake and intracellular transport of acidic FGF was studied in cells transfected with FGF receptor 4 (FGFR4). Acidification of the cytosol to block endocytic uptake from coated pits did not inhibit endocytosis of the growth factor in COS cells transfected with FGFR4, indicating that it is to a large extent taken up by an alternative endocytic pathway. Fractionation of the cells demonstrated that part of the growth factor receptor was present in a low-density, caveolin-containing fraction, but we were unable to demonstrate binding to caveolin in immunoprecipitation studies. Upon treatment of the cells with acidic FGF, the activated receptor, together with the growth factor, moved to a juxtanuclear compartment, which was identified as the recycling endosome compartment. When the cells were lysed with Triton X-100, 3-([3-chloramidopropyl]dimethylammonio)-2-hydroxy-1-propanesulfona te, or 2-octyl glucoside, almost all surface-exposed and endocytosed FGFR4 was solubilized, but only a minor fraction of the total FGFR4 in the cells was found in the soluble fraction. The data indicate that the major part of FGFR4 is anchored to detergent-insoluble structures, presumably cytoskeletal elements associated with the recycling endosome compartment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.