ArticleMolecular biology of the cell1999
Nuclear domains enriched in RNA 3'-processing factors associate with coiled bodies and histone genes in a cell cycle-dependent manner.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- The fission yeast ortholog of Coilin, Mug174, forms Cajal body-like nuclear condensates and is essential for cellular quiescence.Nucleic acids research · 2024Article
- Liquid-liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept.Cellular and molecular life sciences : CMLS · 2022Review
- Three-Dimensional Image of Cleavage Bodies in Nuclei Is Configured Using Gas Cluster Ion Beam with Time-of-Flight Secondary Ion Mass Spectrometry.Scientific reports · 2015Article
- The abbreviated pluripotent cell cycle.Journal of cellular physiology · 2013Review
- The architectural organization of human stem cell cycle regulatory machinery.Current pharmaceutical design · 2012Review
- Gene positioning.Cold Spring Harbor perspectives in biology · 2010Review
- Chromatin position in human HepG2 cells: although being non-random, significantly changed in daughter cells.Journal of structural biology · 2009Article
- Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon?Biochimica et biophysica acta · 2008Review
- Review
- Review
- The Drosophila melanogaster Cajal body.The Journal of cell biology · 2006Article
- Dynamic nature of cleavage bodies and their spatial relationship to DDX1 bodies, Cajal bodies, and gems.Molecular biology of the cell · 2006Article
- Cell cycle-regulated trafficking of human telomerase to telomeres.Molecular biology of the cell · 2006Article
- Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs.Genes & development · 2005Article
- Synergistic transcription activation by Maf and Sox and their subnuclear localization are disrupted by a mutation in Maf that causes cataract.Molecular and cellular biology · 2004Article
- Finding a role for PML in APL pathogenesis: a critical assessment of potential PML activities.Leukemia · 2002Review
- Pondering the promyelocytic leukemia protein (PML) puzzle: possible functions for PML nuclear bodies.Molecular and cellular biology · 2002Review
- Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA.Molecular biology of the cell · 2001Article
- Functional architecture in the cell nucleus.The Biochemical journal · 2001Review
- Replication-dependent histone gene expression is related to Cajal body (CB) association but does not require sustained CB contact.Molecular biology of the cell · 2001Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear domains, called cleavage bodies, are enriched in the RNA 3'-processing factors CstF 64 kDa and and CPSF 100 kDa. Cleavage bodies have been found either overlapping with or adjacent to coiled bodies. To determine whether the spatial relationship between cleavage bodies and coiled bodies was influenced by the cell cycle, we performed cell synchronization studies. We found that in G1 phase cleavage bodies and coiled bodies were predominantly coincident, whereas in S phase they were mostly adjacent to each other. In G2 cleavage bodies were often less defined or absent, suggesting that they disassemble at this point in the cell cycle. A small number of genetic loci have been reported to be juxtaposed to coiled bodies, including the genes for U1 and U2 small nuclear RNA as well as the two major histone gene clusters. Here we show that cleavage bodies do not overlap with small nuclear RNA genes but do colocalize with the histone genes next to coiled bodies. These findings demonstrate that the association of cleavage bodies and coiled bodies is both dynamic and tightly regulated and suggest that the interaction between these nuclear neighbors is related to the cell cycle-dependent expression of histone genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.