ArticleMolecular biology of the cell1999
Genetic and biochemical characterization of the yeast spo12 protein.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Cdc14 Early Anaphase Release, FEAR, Is Limited to the Nucleus and Dispensable for Efficient Mitotic Exit.PloS one · 2015Article
- Regulation of Spo12 phosphorylation and its essential role in the FEAR network.Current biology : CB · 2009Article
- The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae.Genetics · 2006Article
- The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Genetic analysis of apomictic wine yeasts.Current genetics · 2004Article
- The role of the polo kinase Cdc5 in controlling Cdc14 localization.Molecular biology of the cell · 2003Article
- Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2.Genes & development · 2003Article
- Spo13 protects meiotic cohesin at centromeres in meiosis I.Genes & development · 2002Article
- The G1/S cyclin Cig2p during meiosis in fission yeast.Molecular biology of the cell · 2002Article
- The Saccharomyces cerevisiae Fin1 protein forms cell cycle-specific filaments between spindle pole bodies.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Article
- Recombination can partially substitute for SPO13 in regulating meiosis I in budding yeast.Genetics · 2000Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have performed a genetic and biochemical analysis of the SPO12 gene, which regulates meiotic nuclear divisions in budding yeast. When sporulated, spo12 mutants undergo a single meiotic nuclear division most closely resembling meiosis II. We observed that Spo12 protein is localized to the nucleus during both meiotic divisions and that Clb1-Cdc28, Clb3-Cdc28, Clb4-Cdc28, and Clb5-Cdc28 kinase activities during meiosis were not affected by a spo12 mutation. Using two-hybrid analysis, we identified several genes, three of which are meiotically induced, that may code for proteins that interact with Spo12p. We also observed that two genes, BNS1 (Bypasses Need for Spo12p), which has homology to SPO12, and SPO13, whose mutant phenotype is like that of spo12, can partially suppress the meiotic defect of spo12 mutants when overexpressed. We found that Spo12p is also localized to the nucleus in vegetative cells and that its level peaks during G2/M. We observed that a spo12 mutation is synthetically lethal in vegetative cells with a mutation in HCT1, a gene necessary for cells to exit mitosis, suggesting that Spo12p may have a role in exit from mitosis.
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