ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners1999
Long-term prescribing of proton pump inhibitors in general practice.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Lansoprazole for persistent throat symptoms in secondary care: the TOPPITS RCT.Health technology assessment (Winchester, England) · 2021Trial
- Randomized, multicenter study: on-demand versus continuous maintenance treatment with esomeprazole in patients with non-erosive gastroesophageal reflux disease.BMC gastroenterology · 2016Trial
- Trial
- Treatment strategies for reflux esophagitis including a potassium-competitive acid blocker: A cost-effectiveness analysis in Japan.Journal of general and family medicine · 2021Article
- A Cross-Sectional Study on Single-Day Use of Proton Pump Inhibitors in Tertiary Care Hospitals of South India.Hospital pharmacy · 2021Article
- When does proton pump inhibitor treatment become long term? A scoping review.BMJ open gastroenterology · 2021Article
- On-Demand Therapy with Proton Pump Inhibitors for Maintenance Treatment of Nonerosive Reflux Disease or Mild Erosive Esophagitis: A Systematic Review and Meta-Analysis.Gastroenterology research and practice · 2018Review
- Use of proton-pump inhibitors among adults: a Danish nationwide drug utilization study.Therapeutic advances in gastroenterology · 2016Article
- Long-Term PPI Use: Balancing Potential Harms and Documented Benefits.The American journal of gastroenterology · 2016Article
- A benefit-risk assessment of the use of proton pump inhibitors in the elderly.Drugs & aging · 2014Review
- Helicobacter Pylori "Test-and-Treat" Strategy for Management of Dyspepsia: A Comprehensive Review.Clinical and translational gastroenterology · 2013Article
- Appropriateness of treatment recommendations for PPI in hospital discharge letters.European journal of clinical pharmacology · 2010Article
- Tailored antireflux surgery.The journal of nutrition, health & aging · 2008Article
- Comparing resource utilization and gastrointestinal outcomes in patients treated with either standard-dose or high-dose proton pump inhibitors: a matched cohort study.Digestive diseases and sciences · 2008Article
- Characterizing early prescribers of newly marketed drugs in Canada: a population-based study.European journal of clinical pharmacology · 2007Article
- Long-term management of GERD in the elderly with pantoprazole.Clinical interventions in aging · 2007Review
- Acceptability of lansoprazole orally disintegrating tablets in patients with gastro-oesophageal reflux disease : ACEPTO study.Clinical drug investigation · 2007Article
- Does gastric acid suppression increase the risk of community-acquired pneumonia?CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2005Article
- Clinical pharmacology of proton pump inhibitors: what the practising physician needs to know.Drugs · 2003Review
- Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProton pump inhibitors (PPIs) constitute the largest sector of the National Health Service (NHS) community drugs bill (238 m Pounds; 5.6%). Little is known of the long-term prescribing component of this.
aimTo study the extent, the reasons for, and the cost implications of the long-term prescription of PPIs in general practice.
methodSubjects on long-term therapy were identified by searches of computerized and paper records from three practices, comprising 21 GPs with 46,650 patients, representing a population cross section in north-east England.
resultsTwo hundred and nine (0.45%) patients were on long-term PPIs (range between practices = 0.3% to 0.55%): 87% were on omeprazole, 13% lansoprazole; average age = 60 years (male = 56 years, female = 64 years; range = 14 to 91 years); male to female ratio = 47:53. The main indications were 'reflux' (39%), 'oesophagitis' (17%), non-specified 'dyspepsia' (24%), 'peptic ulcer' (8%). During the study year, 1952 prescriptions (28-day courses) were issued: a mean of nine per patient (range = 1 to 8). Sixteen per cent of patients requested fewer than six prescriptions, 27% requested between six and nine prescriptions, and only 21% requested sufficient prescriptions for the entire year. The average cost was 3707 Pounds per general practitioner per annum, or 320,000 Pounds for the district, representing 40% of the total PPI bill.
conclusionOf the total population, 0.45% were prescribed long-term PPIs; most for symptom relief. The long-term component comprised 40% of all PPI costs estimated at 100 million Pounds per annum for the United Kingdom. Most patients took their treatment only intermittently. More research is needed into strategies for rationalization of long-term PPI therapy. For most patients, doctors can advise on-demand rather than regular once-daily therapy.
Indexed as
Identifiers
10562744PMC1313442What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.