ArticleThe Journal of experimental medicine1999
A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- Experimental validation and comprehensive analysis of m6A methylation regulators in intervertebral disc degeneration subpopulation classification.Scientific reports · 2024Article
- T cell receptor (TCR) signaling in health and disease.Signal transduction and targeted therapy · 2021Review
- Reversing Post-Infectious Epigenetic-Mediated Immune Suppression.Frontiers in immunology · 2021Review
- Topical Application of Temperature-Sensitive Gel Containing Caerin 1.1 and 1.9 Peptides on TC-1 Tumour-Bearing Mice Induced High-Level Immune Response in the Tumour Microenvironment.Frontiers in oncology · 2021Article
- How the Discovery of the CD4/CD8-p56Frontiers in cell and developmental biology · 2021Review
- Induction and stability of the anergic phenotype in T cells.Seminars in immunology · 2013Review
- A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- T-cell signaling regulated by the Tec family kinase, Itk.Cold Spring Harbor perspectives in biology · 2010Review
- Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.Immunological reviews · 2009Review
- Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Bam32: a novel mediator of Erk activation in T cells.International immunology · 2008Article
- Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.Clinical and experimental immunology · 2007Article
- Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.The Journal of experimental medicine · 2005Article
- Regulation of T-cell receptor signalling by membrane microdomains.Immunology · 2004Review
- Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing.Molecular biology of the cell · 2004Article
- Differential expression of mRNA for Th1 and Th2 cytokine-associated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitis.Clinical and experimental immunology · 2004Article
- Activation-induced modification in the CD3 complex of the gammadelta T cell receptor.The Journal of experimental medicine · 2002Article
- Tec family kinases modulate thresholds for thymocyte development and selection.The Journal of experimental medicine · 2000Article
- Function of CD3 epsilon-mediated signals in T cell development.The Journal of experimental medicine · 2000Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent data indicate that several members of the Tec family of protein tyrosine kinases function in antigen receptor signal transduction. Txk, a Tec family protein tyrosine kinase, is expressed in both immature and mature T cells and in mast cells. By overexpressing Txk in T cells throughout development, we found that Txk specifically augments the phospholipase C (PLC)-gamma1-mediated calcium signal transduction pathway upon T cell antigen receptor (TCR) engagement. Although Txk is structurally different from inducible T cell kinase (Itk), another Tec family member expressed in T cells, expression of the Txk transgene could partially rescue defects in positive selection and signaling in itk(-)(/)(-) mice. Conversely, in the itk(+/+) (wild-type) background, overexpression of Txk inhibited positive selection of TCR transgenic thymocytes, presumably due to induction of cell death. These results identify a role for Txk in TCR signal transduction, T cell development, and selection and suggest that the Tec family kinases Itk and Txk perform analogous functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.