ArticleThe Journal of clinical investigation1999
Regulation of smooth muscle cell migration and integrin expression by the Gax transcription factor.
Article in The Journal of clinical investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 83 citations in OpenAlex.
- Vascular smooth muscle cell state trajectories mediate molecular mechanisms of coronary disease risk.Nature communications · 2026Article
- Microvascular smooth muscle cells exhibit divergent phenotypic switching responses to platelet-derived growth factor and insulin-like growth factor 1.Microvascular research · 2024Article
- Inhibition of integrin alpha v/beta 5 mitigates the protective effect induced by irisin in hemorrhage.Experimental and molecular pathology · 2023Article
- Meox2 Haploinsufficiency Accelerates Axonal Degeneration in DBA/2J Glaucoma.Investigative ophthalmology & visual science · 2019Article
- Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells.Nature communications · 2018Article
- Article
- Saponin extract from Panax notoginseng promotesangiogenesis through AMPK‑ and eNOS‑dependent pathways in HUVECs.Molecular medicine reports · 2017Article
- Gax regulates human vascular smooth muscle cell phenotypic modulation and vascular remodeling.American journal of translational research · 2016Article
- p55γ functional mimetic peptide N24 blocks vascular proliferative disorders.Journal of molecular medicine (Berlin, Germany) · 2015Article
- The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migration.The Journal of biological chemistry · 2015Article
- Matricellular protein Cyr61 bridges lysophosphatidic acid and integrin pathways leading to cell migration.The Journal of biological chemistry · 2014Article
- Analysis of homeobox gene action may reveal novel angiogenic pathways in normal placental vasculature and in clinical pregnancy disorders associated with abnormal placental angiogenesis.Frontiers in pharmacology · 2014Review
- Growth arrest-specific homeobox is associated with poor survival in patients with hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2012Article
- miR-301a is a candidate oncogene that targets the homeobox gene Gax in human hepatocellular carcinoma.Digestive diseases and sciences · 2012Article
- Beta3 integrin haplotype influences gene regulation and plasma von Willebrand factor activity.Atherosclerosis · 2008Article
- Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.Molecular oncology · 2007Article
- The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences.The Journal of biological chemistry · 2007Article
- Critical role for the Ets transcription factor ELF-1 in the development of tumor angiogenesis.Blood · 2006Article
- A cell-cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis.Arthritis research & therapy · 2006Article
- Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Homeobox transcription factors specify body plan by regulating differentiation, proliferation, and migration at a cellular level. The homeobox transcription factor Gax is expressed in quiescent vascular smooth muscle cells (VSMCs), and its expression is downregulated by vascular injury or other conditions that lead to VSMC proliferation. Previous investigations demonstrate that Gax may regulate VSMC proliferation by upregulating the cyclin-dependent kinase (cdk) inhibitor p21. Here we examined whether Gax influences VSMC migration, a key feature in the development of stenotic lesions after balloon injury. Transduction of a Gax cDNA inhibited the migratory response of VSMCs toward PDGF-BB, basic fibroblast growth factor, or hepatocyte growth factor/scatter factor. Gax expression also inhibited migration of NIH.3T3 fibroblasts and embryonic fibroblasts lacking p53. Gax was unable to inhibit the migration of fibroblasts lacking p21, but this effect could be restored in these cells by providing exogenous p21 or by overexpressing another cdk inhibitor, p16. Flow cytometric analysis implicated a Gax-mediated downregulation of alpha(v)beta(3) and alpha(v)beta(5) integrin expression in VSMCs as a potential cause for reduced cell motility. Gax specifically downregulated beta(3) and beta(5) in VSMCs in culture and after acute vascular injury in vivo. Repression of integrin expression was also found in NIH 3T3 cells and p53 knockout fibroblasts, but not in p21-knockout fibroblasts, unless these cells express exogenous p21 or p16. These data suggest that cycle progression, integrin expression, and cell migration can be regulated in VSMCs by the homeobox gene product Gax.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.