ArticleThe Journal of clinical investigation1999
Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice.
Article in The Journal of clinical investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 81 citations in OpenAlex.
- Involvement of Nitric Oxide in Protecting against Radical Species and Autoregulation of M1-Polarized Macrophages through Metabolic Remodeling.Molecules (Basel, Switzerland) · 2023Review
- Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Inhibition of overexpressed Kv3.4 augments HPV in endotoxemic mice.BMC pulmonary medicine · 2020Article
- Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia.Respiratory research · 2019Article
- Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia.Respiratory research · 2018Article
- Soluble epoxide hydrolase deficiency or inhibition enhances murine hypoxic pulmonary vasoconstriction after lipopolysaccharide challenge.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice.Respiratory research · 2015Article
- Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration.PloS one · 2015Article
- Hypoxic pulmonary vasoconstriction.Physiological reviews · 2012Review
- Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice.Anesthesiology · 2011Article
- Nitric oxide synthase 3 contributes to ventilator-induced lung injury.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- Regulatory T cell-mediated resolution of lung injury: identification of potential target genes via expression profiling.Physiological genomics · 2010Article
- Determinants of regional ventilation and blood flow in the lung.Intensive care medicine · 2009Review
- Pretreatment with N-nitro-L-arginine methyl ester improved oxygenation after inhalation of nitric oxide in newborn piglets with Escherichia coli pneumonia and sepsis.Journal of Korean medical science · 2006Article
- Leukotrienes in acute lung injury: a potential therapeutic target?American journal of respiratory and critical care medicine · 2005Article
- Inhaled nitric oxide therapy in adults: European expert recommendations.Intensive care medicine · 2005Article
- 5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury.American journal of respiratory and critical care medicine · 2005Article
- Modulation of hypoxic pulmonary vasoconstriction is time and nitric oxide dependent in a peritonitis model of sepsis.Intensive care medicine · 2004Article
- Recipient iNOS but not eNOS deficiency reduces luminal narrowing in tracheal allografts.The Journal of experimental medicine · 2002Article
- Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction.The Journal of clinical investigation · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sepsis and endotoxemia impair hypoxic pulmonary vasoconstriction (HPV), thereby reducing arterial oxygenation and enhancing hypoxemia. Endotoxin induces nitric oxide (NO) production by NO synthase 2 (NOS2). To assess the role of NO and NOS2 in the impairment of HPV during endotoxemia, we measured in vivo the distribution of total pulmonary blood flow (QPA) between the right (QRPA) and left (QLPA) pulmonary arteries before and after left mainstem bronchus occlusion (LMBO) in mice with and without a congenital deficiency of NOS2. LMBO reduced QLPA/QPA equally in saline-treated wild-type and NOS2-deficient mice. However, prior challenge with Escherichia coli endotoxin markedly impaired the ability of LMBO to reduce QLPA/QPA in wild-type, but not in NOS2-deficient, mice. After endotoxin challenge and LMBO, systemic oxygenation was impaired to a greater extent in wild-type than in NOS2-deficient mice. When administered shortly after endotoxin treatment, the selective NOS2 inhibitor L-NIL preserved HPV in wild-type mice. High concentrations of inhaled NO attenuated HPV in NOS2-deficient mice challenged with endotoxin. These findings demonstrate that increased pulmonary NO levels (produced by NOS2 or inhaled at high levels from exogenous sources) are necessary during the septic process to impair HPV, ventilation/perfusion matching and arterial oxygenation in a murine sepsis model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.