ArticleThe Plant cell1999
Expression of Arabidopsis CAX1 in tobacco: altered calcium homeostasis and increased stress sensitivity.
Article in The Plant cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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Who cites it
98 citing papers in PubMed.
- Advances in Imaging of Plant CaBiomolecules · 2026Review
- Identification of the cation/H+ exchanger genes in peanut and functional analysis ofFrontiers in plant science · 2026Article
- CAX1 beyond calcium transport: evidence for a transport-independent regulatory module in plants.Frontiers in plant science · 2026Review
- Structural basis of CAX1 autoinhibition by its amino-terminal domain in Arabidopsis thaliana.Nature plants · 2025Article
- Time-Series Elemental Imaging Reveals CAX-Dependent Redistribution Patterns for Anoxia Recovery.Journal of experimental botany · 2025Article
- Article
- Functional differentiation and genetic diversity of rice cation exchanger (CAX) genes and their potential use in rice improvement.Scientific reports · 2024Article
- Inhibition of NPR1 Leads to Shoot Growth Improvement under Low-Calcium Conditions in Arabidopsis.Plant & cell physiology · 2023Article
- Genome-Wide Identification ofGenes · 2023Article
- CaCommunications biology · 2023Article
- MdbHLH4 negatively regulates apple cold tolerance by inhibiting MdCBF1/3 expression and promoting MdCAX3L-2 expression.Plant physiology · 2023Article
- Interventions to improve calcium intake through foods in populations with low intake.Annals of the New York Academy of Sciences · 2022Review
- The E3 Ubiquitin Ligase GeneAntioxidants (Basel, Switzerland) · 2022Article
- Calcium channels and transporters: Roles in response to biotic and abiotic stresses.Frontiers in plant science · 2022Review
- Transport, functions, and interaction of calcium and manganese in plant organellar compartments.Plant physiology · 2021Review
- Identification of genes related to tipburn resistance in Chinese cabbage and preliminary exploration of its molecular mechanism.BMC plant biology · 2021Article
- The Rice Cation/HInternational journal of molecular sciences · 2021Article
- Chlamydomonas reinhardtii cellular compartments and their contribution to intracellular calcium signalling.Journal of experimental botany · 2021Review
- Phylogenetic and ion-response analyses reveal a relationship between gene expansion and functional divergence in the CaPlant molecular biology · 2021Article
- Metabolomic and transcriptomic analyses of mutant yellow leaves provide insights into pigment synthesis and metabolism in Ginkgo biloba.BMC genomics · 2020Article
38 more citing papers are in PubMed but not listed here.
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1 author.
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Abstract
Calcium (Ca(2)+) efflux from the cytosol modulates Ca(2+) concentrations in the cytosol, loads Ca(2+) into intracellular compartments, and supplies Ca(2+) to organelles to support biochemical functions. The Ca(2+)/H(+) antiporter CAX1 (for CALCIUM EXCHANGER 1) of Arabidopsis is thought to be a key mediator of these processes. To clarify the regulation of CAX1, we examined CAX1 RNA expression in response to various stimuli. CAX1 was highly expressed in response to exogenous Ca(2+). Transgenic tobacco plants expressing CAX1 displayed symptoms of Ca(2+) deficiencies, including hypersensitivity to ion imbalances, such as increased magnesium and potassium concentrations, and to cold shock, but increasing the Ca(2+) in the media abrogated these sensitivities. Tobacco plants expressing CAX1 also demonstrated increased Ca(2+) accumulation and altered activity of the tonoplast-enriched Ca(2+)/H(+) antiporter. These results emphasize that regulated expression of Ca(2+)/H(+) antiport activity is critical for normal growth and adaptation to certain stresses.
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