ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Embryonic neurons adapt to the inhibitory proteoglycan aggrecan by increasing integrin expression.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 123 citations in OpenAlex.
- Article
- Retinal inputs signal astrocytes to recruit interneurons into visual thalamus.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Advances in the Signaling Pathways Downstream of Glial-Scar Axon Growth Inhibitors.Frontiers in cellular neuroscience · 2020Review
- Epac2 Elevation Reverses Inhibition by Chondroitin Sulfate ProteoglycansThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Identification and characterization of synthetic chondroitin-4-sulfate binding peptides in neuronal functions.Scientific reports · 2019Article
- Grafted Human iPSC-Derived Neural Progenitor Cells Express Integrins and Extend Long-Distance Axons Within the Developing Corticospinal Tract.Frontiers in cellular neuroscience · 2019Article
- Diverse functions of protein tyrosine phosphatase σ in the nervous and immune systems.Experimental neurology · 2018Review
- Review
- Effect of chondroitin sulfate proteoglycans on neuronal cell adhesion, spreading and neurite growth in culture.Neural regeneration research · 2018Article
- Environmental cues determine the fate of astrocytes after spinal cord injury.Neural regeneration research · 2017Review
- Two PTP receptors mediate CSPG inhibition by convergent and divergent signaling pathways in neurons.Scientific reports · 2016Article
- Molecular mechanisms of scar-sourced axon growth inhibitors.Brain research · 2015Review
- Cocaine Causes Apoptotic Death in Rat Mesencephalon and Striatum Primary Cultures.BioMed research international · 2015Article
- Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury.Neurobiology of disease · 2015Article
- Entrapment via synaptic-like connections between NG2 proteoglycan+ cells and dystrophic axons in the lesion plays a role in regeneration failure after spinal cord injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Axon plasticity in the mammalian central nervous system after injury.Trends in neurosciences · 2014Review
- Isolation and culture of dissociated sensory neurons from chick embryos.Journal of visualized experiments : JoVE · 2014Article
- Contributions of chondroitin sulfate proteoglycans to neurodevelopment, injury, and cancer.Current opinion in neurobiology · 2014Review
- Proteoglycans: road signs for neurite outgrowth.Neural regeneration research · 2014Article
- Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The primary mediators of cell migration during development, wound healing and metastasis, are receptors of the integrin family. In the developing and regenerating nervous system, chondroitin sulfate proteoglycans (CSPGs) inhibit the integrin-dependent migration of neuronal growth cones. Here we report that embryonic sensory neurons cultured on the growth-promoting molecule laminin in combination with the inhibitory CSPG aggrecan rapidly adapt to inhibition. Adaptation is associated with a two- to threefold increase in the levels of RNA and surface protein for two laminin receptors, integrin alpha6beta1 and alpha3beta1, indicating that integrin expression is regulated by aggrecan. Increased integrin expression is associated both with increases in neuronal cell adhesion/outgrowth and with decreases in the ability of aggrecan to inhibit cell adhesion. Directly increasing integrin expression by adenoviral infection is sufficient to eliminate the inhibitory effects of aggrecan, indicating that upregulation of integrin receptors may promote neuronal regeneration in the presence of inhibitory matrix components.
Indexed as
Identifiers
10559411PMC6782993W1941658825What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.