ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Expression of the voltage-gated chloride channel ClC-2 in rod bipolar cells of the rat retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- ClC-2 Contributes to Hypotonicity-Induced Adrenal Aldosterone Secretion.Acta physiologica (Oxford, England) · 2026Article
- Chloride Homeostasis in Neuronal Disorders: Bridging Measurement to Therapy.Life (Basel, Switzerland) · 2025Review
- IK Channel Confers Fine-tuning of Rod Bipolar Cell Excitation and Synaptic Transmission in the Retina.Function (Oxford, England) · 2025Article
- ClC-2-like Chloride Current Alterations in a Cell Model of Spinal and Bulbar Muscular Atrophy, a Polyglutamine Disease.Journal of molecular neuroscience : MN · 2021Article
- Research and progress on ClC‑2 (Review).Molecular medicine reports · 2017Review
- Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei.PloS one · 2017Article
- Chloride channel protein 2 prevents glutamate-induced apoptosis in retinal ganglion cells.Iranian journal of basic medical sciences · 2016Article
- Response to comments on "Local impermeant anions establish the neuronal chloride concentration".Science (New York, N.Y.) · 2014Article
- Increase in hypotonic stress-induced endocytic activity in macrophages via ClC-3.Molecules and cells · 2014Article
- Chloride channelopathies of ClC-2.International journal of molecular sciences · 2013Review
- Cellular elements for seeing in the dark: voltage-dependent conductances in cockroach photoreceptors.BMC neuroscience · 2012Article
- What is the functional role of the thalidomide binding protein cereblon?International journal of biochemistry and molecular biology · 2011Article
- Nonsynaptic communication through ATP release from volume-activated anion channels in axons.Science signaling · 2010Article
- Inward-rectifier chloride currents in Reissner's membrane epithelial cells.Biochemical and biophysical research communications · 2010Article
- A synthetic prostone activates apical chloride channels in A6 epithelial cells.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Identification of ClC-2 and CIC-K2 chloride channels in cultured rat type IV spiral ligament fibrocytes.Journal of the Association for Research in Otolaryngology : JARO · 2007Article
- Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes.The Journal of physiology · 2006Article
- Putative ClC-2 chloride channel mediates inward rectification in Drosophila retinal photoreceptors.The Journal of membrane biology · 2005Article
- Article
- Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Voltage-gated chloride channels (ClC) are highly conserved during evolution and appear to participate in a variety of physiological functions. Recently, ClC-2 was proposed to play a role in stabilizing the chloride equilibrium potential near or below the resting membrane potential in neurons expressing ligand-gated chloride channels. Because rod bipolar cells in mammalian retina express three forms of inhibitory ligand-gated chloride channels, we decided to study ClC-2 localization and function in the rat retina. RNA encoding ClC-1, -2, -3, -4, and -5 was detected by reverse transcription-PCR in the rat retina. ClC-2-specific antibodies identified protein on cell bodies and in synaptic layers. Double-immunofluorescence staining revealed that intense ClC-2 immunoreactivity colocalized with PKC-stained rod bipolar cells. Patch-clamp experiments performed with individual rod bipolar cells demonstrated the presence of a time-dependent, inwardly rectified current activated at hyperpolarizing membrane potentials. This current demonstrated selectivity for different anions (Cl(-) > I(-) > gluconate), was inhibited by Cd(2+), and was minimally reduced by 4,4'-diisothiocyanatostilbene-2,2'-disulphonic acid. These features are consistent with currents generated by ClC-2 channels. Our data indicate that functional ClC-2 channels are present in retinal rod bipolar cells and support a role for ClC-2 in maintaining Cl(-) homeostasis in neurons with ligand-gated chloride channels.
Indexed as
Identifiers
10559393PMC6782979W1854462055What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.