ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Block of an ether-a-go-go-like K(+) channel by imipramine rescues egl-2 excitation defects in Caenorhabditis elegans.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 84 citations in OpenAlex.
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- Phenotypic and functional assessment of two novel KCNQ2 gain-of-function variants Y141N and G239S and effects of amitriptyline treatment.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Article
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- A microbial metabolite synergizes with endogenous serotonin to triggerProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Dynamic Regulation of Adult-Specific Functions of the Nervous System by Signaling from the Reproductive System.Current biology : CB · 2019Article
- Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism.PLoS biology · 2019Article
- Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD.PloS one · 2019Article
- Sexual Dimorphism and Sex Differences inGenetics · 2018Article
- TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C. elegans.Neuron · 2018Article
- Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans.Scientific reports · 2017Article
- Activity of theeLife · 2016Article
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- KChIP-like auxiliary subunits of Kv4 channels regulate excitability of muscle cells and control male turning behavior during mating in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron.Journal of cell science · 2014Article
- An open-source analytical platform for analysis of C. elegans swimming-induced paralysis.Journal of neuroscience methods · 2014Article
- Drug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs.Frontiers in pharmacology · 2014Review
- Potential conservation of circadian clock proteins in the phylum Nematoda as revealed by bioinformatic searches.PloS one · 2014Article
- Postsynaptic ERG potassium channels limit muscle excitability to allow distinct egg-laying behavior states in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
K(+) channels are key regulators of cellular excitability. Mutations that activate K(+) channels can lower cellular excitability, whereas those that inhibit K(+) channels may increase excitability. We show that the Caenorhabditis elegans egl-2 gene encodes an eag K(+) channel and that a gain-of-function mutation in egl-2 blocks excitation in neurons and muscles by causing the channel to open at inappropriately negative voltages. Tricyclic antidepressants reverse egl-2(gf) mutant phenotypes, suggesting that EGL-2 is a tricyclic target. We verified this by showing that EGL-2 currents are inhibited by imipramine. Similar inhibition is observed with the mouse homolog MEAG, suggesting that inhibition of EAG-like channels may mediate some clinical side effects of this class of antidepressants.
Indexed as
Identifiers
10559392PMC6782970W1762858688What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.