ArticleJournal of virology1999
The equine herpesvirus 2 E1 open reading frame encodes a functional chemokine receptor.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Gammaherpesvirus infections in equids: a review.Veterinary medicine (Auckland, N.Z.) · 2015Review
- International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.Pharmacological reviews · 2014Review
- Evolutionary Analysis of Functional Divergence among Chemokine Receptors, Decoy Receptors, and Viral Receptors.Frontiers in microbiology · 2012Article
- Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors.British journal of pharmacology · 2008Review
- Epstein-Barr virus infection negatively impacts the CXCR4-dependent migration of tonsillar B cells.Immunology · 2006Article
- Simian cytomegalovirus encodes five rapidly evolving chemokine receptor homologues.Virus genes · 2004Article
- Viral exploitation and subversion of the immune system through chemokine mimicry.Nature immunology · 2001Review
- Evolutionary aspects of oncogenic herpesviruses.Molecular pathology : MP · 2000Review
- Viral mechanisms of immune evasion.Trends in microbiology · 2000Review
- Viral mechanisms of immune evasion.Molecular medicine today · 2000Review
- Viral mechanisms of immune evasion.Immunology today · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several herpesviruses contain open reading frames (ORFs) that encode potential homologs of eucaryotic genes. Equine herpesvirus 2 (EHV-2) is a gammaherpesvirus related to other lymphotropic herpesviruses such as herpesvirus saimiri and Epstein-Barr virus. The E1 ORF of EHV-2, a G protein-coupled receptor homolog, shows 31 to 47% amino acid identity with known CC chemokine receptors. To investigate whether E1 may encode a functional receptor, we cloned the E1 ORF and expressed it in stably transfected cell lines. We report here the identification of the CC chemokine eotaxin as a functional ligand for the EHV-2 E1 receptor. Chemokines are likely to play a role in the regulation of immune functions in equine hosts during EHV-2 infection and, via interaction with E1, may affect viral replication and/or escape from immune responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.