ArticleBiochemical and biophysical research communications1999
Identification and characterization of a transcriptional silencer upstream of the human BRCA2 gene.
Article in Biochemical and biophysical research communications, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- The role of the redox/miR-6855-3p/PRDX5A axis in reversing SLUG-mediated BRCA2 silencing in breast cancer cells.Cell communication and signaling : CCS · 2020Article
- SNP located in anThe British journal of ophthalmology · 2019Article
- Non-Coding Variants inCancers · 2018Review
- Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells.Molecular cancer · 2010Article
- Retroelements and their impact on genome evolution and functioning.Cellular and molecular life sciences : CMLS · 2009Review
- ALU repeats in promoters are position-dependent co-response elements (coRE) that enhance or repress transcription by dimeric and monomeric progesterone receptors.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Differential repression of human and mouse TERT genes during cell differentiation.Nucleic acids research · 2009Article
- Evolutionary rate heterogeneity of Alu repeats upstream of the APOA5 gene: do they regulate APOA5 expression?Journal of human genetics · 2008Article
- Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells.The Journal of biological chemistry · 2005Article
- Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells.Biochemical and biophysical research communications · 2005Article
- Alternative initiation and splicing in dicer gene expression in human breast cells.Breast cancer research : BCR · 2005Article
- Enhanced activity of antisense phosphorothioate oligos against leishmania amastigotes: augmented uptake of oligo, ribonuclease H activation, and efficient target intervention under altered growth conditions.Biochemical pharmacology · 2001Article
- Increased efficacy of antileishmanial antisense phosphorothioate oligonucleotides in Leishmania amazonensis overexpressing ribonuclease H.Biochemical pharmacology · 2001Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Expression of the breast cancer susceptibility tumor-suppressor protein BRCA2, a protein potentially involved in DNA recombination repair, is tightly regulated throughout development. We have identified a transcriptional silencer at the distal end of the human BRCA2 gene promoter. This silencer is involved in the negative regulation of the expression of this gene in breast cell lines tested but not in HeLa or HepG2 cells. The 221-base-pair silencer region is characterized by a full-length Alu-repeat. Presence of specific BRCA2 silencer-binding proteins in the breast cell extracts indicates the potential regulation of BRCA2 gene expression by these proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.