ArticleProceedings of the National Academy of Sciences of the United States of America1999
INAF, a protein required for transient receptor potential Ca(2+) channel function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
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- Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors.The Journal of cell biology · 2011Article
- The history of the Drosophila TRP channel: the birth of a new channel superfamily.Journal of neurogenetics · 2010Review
- Why Drosophila to study phototransduction?Journal of neurogenetics · 2010Article
- Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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- Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Phototransduction and retinal degeneration in Drosophila.Pflugers Archiv : European journal of physiology · 2007Review
- The non-dosage compensated Lsp1alpha gene of Drosophila melanogaster escapes acetylation by MOF in larval fat body nuclei, but is flanked by two dosage compensated genes.BMC molecular biology · 2007Article
- Drosophila retinophilin contains MORN repeats and is conserved in humans.Molecular genetics and genomics : MGG · 2007Article
- Systems-level analysis and evolution of the phototransduction network in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade.Journal of cell science · 2006Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The trp gene of Drosophila encodes a subunit of a class of Ca(2+)-selective light-activated channels that carry the bulk of the phototransduction current. Transient receptor potential (TRP) homologs have been identified throughout animal phylogeny. In vertebrates, TRP-related channels have been suggested to mediate "store-operated Ca(2+) entry," which is important in Ca(2+) homeostasis in a wide variety of cell types. However, the mechanisms of activation and regulation of the TRP channel are not known. Here, we report on the Drosophila inaF gene, which encodes a highly eye-enriched protein, INAF, that appears to be required for TRP channel function. A null mutation in this gene significantly reduces the amount of the TRP protein and, in addition, specifically affects the TRP channel function so as to nearly shut down its activity. The inaF mutation also dramatically suppresses the severe degeneration caused by a constitutively active mutation in the trp gene. Although the reduction in the amount of the TRP protein may contribute to these phenotypes, several lines of evidence support the view that inaF mutations also more directly affect the TRP channel function, suggesting that the INAF protein may have a regulatory role in the channel function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.