ArticleProceedings of the National Academy of Sciences of the United States of America1999
Growth of Toxoplasma gondii is inhibited by aryloxyphenoxypropionate herbicides targeting acetyl-CoA carboxylase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 123 citations in OpenAlex.
- Ecological nuance and comparative parasitology of sympatric canids in the Chornobyl Exclusion Zone.International journal for parasitology. Parasites and wildlife · 2026Article
- Review of Toxoplasmosis: What We Still Need to Do.Veterinary sciences · 2025Review
- TheeLife · 2024Article
- Inhibition of chloroplast translation as a new target for herbicides.RSC chemical biology · 2022Article
- Building Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview.Current pediatrics reports · 2022Review
- Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances "Take a Village".Current pediatrics reports · 2022Review
- Toxoplasmosis: Current and Emerging Parasite Druggable Targets.Microorganisms · 2021Review
- Characterization of Acetyl-CoA Carboxylases in the Basal Dinoflagellate Amphidinium carterae.Marine drugs · 2017Article
- Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.Antimicrobial agents and chemotherapy · 2016Review
- Article
- Phylogenetic Analysis of Nucleus-Encoded Acetyl-CoA Carboxylases Targeted at the Cytosol and Plastid of Algae.PloS one · 2015Article
- Structure, activity, and inhibition of the Carboxyltransferase β-subunit of acetyl coenzyme A carboxylase (AccD6) from Mycobacterium tuberculosis.Antimicrobial agents and chemotherapy · 2014Article
- Fatty acid synthesis and pyruvate metabolism pathways remain active in dihydroartemisinin-induced dormant ring stages of Plasmodium falciparum.Antimicrobial agents and chemotherapy · 2014Article
- A survey of innovation through duplication in the reduced genomes of twelve parasites.PloS one · 2014Article
- Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.Biochemistry · 2013Article
- Metabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii.Molecular systems biology · 2013Article
- Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii.ChemMedChem · 2013Article
- Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.Bioorganic & medicinal chemistry letters · 2013Article
- Purification and cellular localization of the Entamoeba histolytica transcarboxylase.Parasitology research · 2012Article
- Babesia bovis: a bipartite signal directs the glutamyl-tRNA synthetase to the apicoplast.Experimental parasitology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Aryloxyphenoxypropionates, inhibitors of the plastid acetyl-CoA carboxylase (ACC) of grasses, also inhibit Toxoplasma gondii ACC. Clodinafop, the most effective of the herbicides tested, inhibits growth of T. gondii in human fibroblasts by 70% at 10 microM in 2 days and effectively eliminates the parasite in 2-4 days at 10-100 microM. Clodinafop is not toxic to the host cell even at much higher concentrations. Parasite growth inhibition by different herbicides is correlated with their ability to inhibit ACC enzyme activity, suggesting that ACC is a target for these agents. Fragments of genes encoding the biotin carboxylase domain of multidomain ACCs of T. gondii, Plasmodium falciparum, Plasmodium knowlesi, and Cryptosporidium parvum were sequenced. One T. gondii ACC (ACC1) amino acid sequence clusters with P. falciparum ACC, P. knowlesi ACC, and the putative Cyclotella cryptica chloroplast ACC. Another sequence (ACC2) clusters with that of C. parvum ACC, probably the cytosolic form.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.