ArticleProceedings of the National Academy of Sciences of the United States of America1999
Different population dynamics of human T cell lymphotropic virus type II in intravenous drug users compared with endemically infected tribes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 92 citations in OpenAlex.
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- Clinical Determinants of HIV-1B Between-Host Evolution and their Association with Drug Resistance in Pediatric Patients.PloS one · 2016Article
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- Seroprevalence of human T-cell lymphotropic viruses types 1 and 2 antibodies in hepatitis C virus-positive patients: manitoba, Canada, 2012-2014.Open forum infectious diseases · 2015Article
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- Cell tropism predicts long-term nucleotide substitution rates of mammalian RNA viruses.PLoS pathogens · 2014Article
- Human T cell lymphotropic virus type 2a strains among HIV type 1-coinfected patients from Brazil have originated mostly from Brazilian Amerindians.AIDS research and human retroviruses · 2013Article
- Rates of viral evolution are linked to host geography in bat rabies.PLoS pathogens · 2012Article
- From molecular genetics to phylodynamics: evolutionary relevance of mutation rates across viruses.PLoS pathogens · 2012Article
- The mode and tempo of hepatitis C virus evolution within and among hosts.BMC evolutionary biology · 2011Article
- A novel methodology for large-scale phylogeny partition.Nature communications · 2011Article
- Evolutionary analysis of the dynamics of viral infectious disease.Nature reviews. Genetics · 2009Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phylogeny of human T cell lymphotropic virus type II (HTLV-II) was investigated by using strains isolated from Amerindian and Pygmy tribes, in which the virus is maintained primarily through mother-to-child transmission via breast-feeding, and strains from intravenous drug users (IDUs), in which spread is mainly blood-borne via needle sharing. Molecular clock analysis showed that HTLV-II has two different evolutionary rates with the molecular clock for the virus in IDUs ticking 150-350 times faster than the one in endemically infected tribes: 2.7 x 10(-4) compared with 1.71/7.31 x 10(-7) nucleotide substitutions per site per year in the long terminal repeat region. This dramatic acceleration of the evolutionary rate seems to be related with the mode of transmission. Mathematical models showed the correlation of these two molecular clocks with an endemic spread of HTLV-II in infected tribes compared with the epidemic spread in IDUs. We also noted a sharp increase in the population size of the virus among IDUs during the last decades probably caused by the worldwide increase in intravenous drug use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.