ArticleProceedings of the National Academy of Sciences of the United States of America1999
Mechanism by which the IFN-beta enhanceosome activates transcription.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Gene regulatory logic of the interferon-β enhancer is characterized by two selectively deployed modes of transcription factor synergy.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Getah virus nonstructural protein 2 suppresses interferon-beta production by interrupting interferon regulatory factor 3 activation.Veterinary research · 2025Article
- Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3.Immunity · 2025Article
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- Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression.The Journal of biological chemistry · 2018Article
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- Chromatin remodeling effects on enhancer activity.Cellular and molecular life sciences : CMLS · 2016Review
- Hepatitis C Virus Driven AXL Expression Suppresses the Hepatic Type I Interferon Response.PloS one · 2015Article
- Role of nucleosome remodeling in neurodevelopmental and intellectual disability disorders.Frontiers in behavioral neuroscience · 2015Review
- 3Cpro of foot-and-mouth disease virus antagonizes the interferon signaling pathway by blocking STAT1/STAT2 nuclear translocation.Journal of virology · 2014Article
- Interferons and interferon regulatory factors in malaria.Mediators of inflammation · 2014Review
- Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15.Journal of virology · 2012Article
- Article
- The C proteins of human parainfluenza virus type 1 limit double-stranded RNA accumulation that would otherwise trigger activation of MDA5 and protein kinase R.Journal of virology · 2011Article
- Histone acetyltransferases as regulators of nonhistone proteins: the role of interferon regulatory factor acetylation on gene transcription.Journal of biomedicine & biotechnology · 2011Review
- XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Construction of a large scale integrated map of macrophage pathogen recognition and effector systems.BMC systems biology · 2010Article
- Optimal transactivation by Epstein-Barr nuclear antigen 1 requires the UR1 and ATH1 domains.Journal of virology · 2009Article
- The C proteins of human parainfluenza virus type 1 (HPIV1) control the transcription of a broad array of cellular genes that would otherwise respond to HPIV1 infection.Journal of virology · 2009Article
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3 authors.
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Abstract
We demonstrate that in contrast to previous findings by using simple synthetic promoters or activators, the natural IFN-beta enhanceosome activates transcription by causing a dramatic increase of the rate by which preinitiation complexes assemble at the promoter. This effect totally depends on the recruitment of the CBP-PolII holoenzyme by the enhanceosome, because its depletion from the extract decelerates the rate of transcription. However, addition of the CBP-PolII holoenzyme back to these extracts fully restores the speed by which the enhanceosome activates transcription. Strikingly, preincubation of the enhanceosome with the CBP-RNA PolII holoenzyme complex results in instant assembly of preinitiation complexes. In contrast, individual IFN-beta gene activators function solely by increasing the number of functional preinitiation complexes and not the rate of their assembly. Thus, fast recruitment of the CBP-RNA PolII holoenzyme complex is critical for the rapid activation of IFN-beta gene expression by virus infection.
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