ArticleProceedings of the National Academy of Sciences of the United States of America1999
The dimensions of the protein import channels in the outer and inner mitochondrial membranes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Effect of β-amyloid on blood-brain barrier properties and function.Biophysical reviews · 2023Review
- Unravelling the neuroprotective mechanisms of carotenes in differentiated human neural cells: Biochemical and proteomic approaches.Food chemistry. Molecular sciences · 2022Article
- Interplay between Mitochondrial Protein Import and Respiratory Complexes Assembly in Neuronal Health and Degeneration.Life (Basel, Switzerland) · 2021Review
- Dependence of PINK1 accumulation on mitochondrial redox system.Aging cell · 2020Article
- Evaluating the Functional Pore Size of Chloroplast TOC and TIC Protein Translocons: Import of Folded Proteins.The Plant cell · 2018Article
- Mitochondrial metabolic regulation by GRP78.Science advances · 2017Article
- An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues.Molecular and cellular biology · 2016Article
- Mitochondria-associated endoplasmic reticulum membrane (MAM) regulates steroidogenic activity via steroidogenic acute regulatory protein (StAR)-voltage-dependent anion channel 2 (VDAC2) interaction.The Journal of biological chemistry · 2015Article
- Regulation of human 3β-hydroxysteroid dehydrogenase type 2 by adrenal corticosteroids and product-feedback by androstenedione in human adrenarche.The Journal of pharmacology and experimental therapeutics · 2015Article
- The mitochondrial oxidase assembly protein1 (Oxa1) insertase forms a membrane pore in lipid bilayers.The Journal of biological chemistry · 2012Article
- Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesis.Frontiers in cellular and infection microbiology · 2012Review
- Inner mitochondrial translocase Tim50 interacts with 3β-hydroxysteroid dehydrogenase type 2 to regulate adrenal and gonadal steroidogenesis.The Journal of biological chemistry · 2011Article
- Decreased cytochrome c oxidase IV expression reduces steroidogenesis.The Journal of pharmacology and experimental therapeutics · 2011Article
- Functional refolding and characterization of two Tom40 isoforms from human mitochondria.The Journal of membrane biology · 2011Article
- The intermembrane space domain of Tim23 is intrinsically disordered with a distinct binding region for presequences.Protein science : a publication of the Protein Society · 2010Article
- Interactions of mitochondrial presequence peptides with the mitochondrial outer membrane preprotein translocase TOM.Biophysical journal · 2010Article
- Redox regulation of protein folding in the mitochondrial intermembrane space.Biochimica et biophysica acta · 2009Review
- Excursion of a single polypeptide into a protein pore: simple physics, but complicated biology.European biophysics journal : EBJ · 2008Article
- Probing the outer mitochondrial membrane in cardiac mitochondria with nanoparticles.Biophysical journal · 2007Article
- Chain Conformations at the Surface of a Polydisperse Amphiphilic Comb Copolymer Film.Macromolecules · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most mitochondrial proteins are imported into mitochondria through transmembrane channels composed largely, and perhaps exclusively, of proteins. We have determined the effective internal diameter of the protein import channel in the mitochondrial outer membrane to be between 20 A and 26 A during translocation. The diameter of the import channel in the inner membrane is smaller than the diameter of the outer membrane import channel. These results were obtained by measuring the effect of rigid steric bulk introduced into precursor proteins on import.
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