Evidence map›Paper›PMID 10557084›Full record

ArticleOncogene1999

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.

A Gazit, A Yaniv, A Bafico, T Pramila, M Igarashi, J Kitajewski, S A Aaronson

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Wnt/β-catenin signaling in cancers and targeted therapies.Signal transduction and targeted therapy · 2021
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017
    Article
  11. Article
  12. Article
  13. Role of Hox genes in stem cell differentiation.World journal of stem cells · 2015
    Review
  14. Wnt signaling and the control of human stem cell fate.Stem cell reviews and reports · 2014
    Review
  15. Review
  16. Review
  17. Review
  18. Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors.Proceedings of the National Academy of Sciences of the United States of America · 2012
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A GazitDepartment of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
A Yaniv
A Bafico
T Pramila
M Igarashi
J Kitajewski
S A Aaronson

Funding

WNT Receptor Signaling and CancerR01CA071672 · NCI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI AARONSON, STUART A · 1997 to 2009
$3.8M
NCI NIH HHS R01-CA71672
6 · The paper itself

Abstract

The human homologue of fz1 (Hfz1) was cloned from a cDNA library. Hfz1 was shown to couple to Wnt signal transduction pathways by its ability to enhance Wnt induced TCF dependent transcription in both autocrine and paracrine modes. Enhanced TCF dependent signaling was dose dependent with respect to both Wnt-3A and Hfz1. Moreover, Hfz1 deletion mutants with truncated carboxy termini showed markedly reduced capacity to enhance Wnt signal transduction. Specificity was demonstrated with respect to signal transduction by different Wnts. While Wnt-3a, -3, -1 and to a lesser extent Wnt-2 cooperated with Hfz1 in the paracrine assay for TCF dependent signaling, neither Wnt-4, -5a, -5b, -6, -7a nor -7b did so, despite similar levels of expression. However, coimmunoprecipitation of Hfz1 with both Wnt-3a and Wnt-5a indicated that TCF dependent signaling in response to Wnts is not determined solely by their ability to bind the receptor. All of these findings provide strong evidence that Hfz1 is a functional partner for certain Wnts in inducing TCF dependent transcription.

Indexed as

Zebrafish ProteinsCell LineCell Transformation, NeoplasticCloning, MolecularDNA-Binding ProteinsFrizzled ReceptorsHumansLymphoid Enhancer-Binding Factor 1Molecular BiologyMolecular Sequence DataMutationProteinsProto-Oncogene ProteinsReceptors, G-Protein-CoupledReceptors, NeurotransmitterSensitivity and SpecificityDNA-Binding ProteinsFrizzled ReceptorsFZD1 protein, humanFzd1 protein, mouseLymphoid Enhancer-Binding Factor 1ProteinsProto-Oncogene ProteinsReceptors, G-Protein-CoupledReceptors, NeurotransmitterTranscription FactorsWnt2 ProteinWNT2 protein, humanWnt3A ProteinWNT3A protein, humanWnt3a protein, mouseWnt3 ProteinWnt4 ProteinWNT4 protein, humanWnt4 protein, mouseWnt4 protein, ratWnt-5a ProteinWNT5A protein, humanWNT6 protein, humanWNT7A protein, humanWnt7a protein, mouseWnt7a protein, ratWnt ProteinsZebrafish Proteins

Identifiers

PMID10557084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.