ArticleBritish journal of pharmacology1999
Role of L-arginine in the deficiency of nitric oxide and airway hyperreactivity after the allergen-induced early asthmatic reaction in guinea-pigs.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.BMC pulmonary medicine · 2017Article
- l-Arginine administration attenuates airway inflammation by altering l-arginine metabolism in an NC/Nga mouse model of asthma.Journal of clinical biochemistry and nutrition · 2015Article
- Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.Journal of biomedical research · 2011Article
- Nitric oxide in asthma physiopathology.ISRN allergy · 2011Article
- Arginase and arginine dysregulation in asthma.Journal of allergy · 2011Article
- Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives.British journal of pharmacology · 2009Review
- Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders.Current molecular medicine · 2008Review
- Arginase and pulmonary diseases.Naunyn-Schmiedeberg's archives of pharmacology · 2008Review
- Asymmetric dimethylarginine induces oxidative and nitrosative stress in murine lung epithelial cells.American journal of respiratory cell and molecular biology · 2007Article
- Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma.Respiratory research · 2006Article
- Genetic polymorphisms in arginase I and II and childhood asthma and atopy.The Journal of allergy and clinical immunology · 2006Article
- Arginase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxation.Respiratory research · 2005Article
- Heparin normalizes allergen-induced nitric oxide deficiency and airway hyperresponsiveness.British journal of pharmacology · 2004Article
- Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness.British journal of pharmacology · 2002Article
- Role of nitric oxide and superoxide in allergen-induced airway hyperreactivity after the late asthmatic reaction in guinea-pigs.British journal of pharmacology · 2001Article
- Inflammatory cell distribution in guinea pig airways and its relationship to airway reactivity.Mediators of inflammation · 2001Article
- Airway reactivity, inflammatory cell influx and nitric oxide in guinea-pig airways after lipopolysaccharide inhalation.British journal of pharmacology · 2000Article
- Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity.British journal of pharmacology · 2000Article
- Deficiency of nitric oxide in polycation-induced airway hyperreactivity.British journal of pharmacology · 1999Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Using a guinea-pig model of allergic asthma, we investigated the role of L-arginine limitation in the allergen-induced deficiency of nitric oxide (NO) and airway hyperreactivity (AHR) after the early asthmatic reaction, by examining the effects of various concentrations of the NO synthase (NOS) substrate on the responsiveness to methacholine of isolated perfused tracheae from unchallenged (control) animals and from animals 6 h after ovalbumin challenge. 2. Preparations from ovalbumin-challenged guinea-pigs showed a 1.9 fold increase in the maximal response (Emax) to intraluminal (IL) administration of methacholine compared to controls (P<0.001). A similar 2.0 fold (P<0.05) increase in Emax to methacholine was observed in control airways incubated with the NOS inhibitor Nomega-nitro-L-arginine methyl ester (L-NAME; 0.1 mM, IL), while L-NAME had no further effect on the airways from ovalbumin-challenged animals. 3. In control airways, extraluminal (EL) administration of 0.3, 1.0 and 5.0 mM L-arginine all suppressed the Emax for methacholine by approximately 40% (P<0.01 all), whereas 5.0 mM D-arginine (EL) had no effect. 4. L-Arginine dose-dependently reduced the AHR to methacholine in tracheae from ovalbumin-challenged guinea-pigs, the responsiveness being normalized in the presence of 5.0 mM L-arginine. As in controls, 5.0 mM D-arginine was without effect. 5. The results demonstrate that deficiency of endogenous NO contributes to the allergen-induced AHR to methacholine after the early asthmatic reaction, which is reversed by exogenous administration of L-arginine. This indicates that limitation of substrate may underly the reduced cNOS activity and subsequent AHR after the acute asthmatic response.
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