ReviewNeurochemical research1999
In vivo fatty acid incorporation into brain phospholipids in relation to signal transduction and membrane remodeling.
Review in Neurochemical research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Membrane Molecular Species Remodeling as a Signature of ω-3 Fatty Acid Action in Cultured Neural Cells.ASN neuro · 2026Article
- Dysregulated hippocampal fatty acid metabolism following intermittent hypoxemia-induced neonatal brain injury is rescued by treatment with acetate.Nature communications · 2025Article
- Bioactive Compounds for Customized Brain Health: What Are We and Where Should We Be Heading?International journal of environmental research and public health · 2023Review
- Palmitate and thapsigargin have contrasting effects on ER membrane lipid composition and ER proteostasis in neuronal cells.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2022Article
- Impaired Membrane Lipid Homeostasis in Schizophrenia.Schizophrenia bulletin · 2022Article
- Lipid and Lipoprotein Metabolism in Microglia.Frontiers in physiology · 2020Review
- Conjugated Linoleic Acid and Brain Metabolism: A Possible Anti-Neuroinflammatory Role Mediated by PPARα Activation.Frontiers in pharmacology · 2020Review
- [Synapse (New York, N.Y.) · 2018Article
- Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls.PloS one · 2018Article
- Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain.Cellular signalling · 2016Article
- Imaging mass spectrometry reveals loss of polyunsaturated cardiolipins in the cortical contusion, hippocampus, and thalamus after traumatic brain injury.Journal of neurochemistry · 2016Article
- Docosahexaenoic Acid and Cognition throughout the Lifespan.Nutrients · 2016Review
- Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease.Brain research · 2015Review
- The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms.Journal of lipid research · 2013Article
- Peroxiredoxin 6 promotes upregulation of the prion protein (PrP) in neuronal cells of prion-infected mice.Cell communication and signaling : CCS · 2012Article
- Role of cytosolic calcium-dependent phospholipase A2 in Alzheimer's disease pathogenesis.Molecular neurobiology · 2012Review
- Temporal changes in mouse brain fatty acid amide hydrolase activity.Neuroscience · 2009Article
- Formation of dopamine adducts derived from brain polyunsaturated fatty acids: mechanism for Parkinson disease.The Journal of biological chemistry · 2008Article
- Deacylation and reacylation of neural membrane glycerophospholipids.Journal of molecular neuroscience : MN · 2000Review
- Plasmalogens, phospholipase A2, and docosahexaenoic acid turnover in brain tissue.Journal of molecular neuroscience : MNReview
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A method and model are described to quantify in vivo turnover rates and half-lives of fatty acids within brain phospholipids. These "kinetic" parameters can be calculated by operational equations from measured rates of incorporation of intravenously injected fatty acid radiotracers into brain phospholipids. To do this, it is necessary to determine a "dilution factor" lambda, which estimates the contribution to the brain precursor acyl-CoA pool of fatty acids released from phospholipids through the action of PLA1 or PLA2. Some calculated fatty acid half-lives are minutes to hours, consistent with active participation of phospholipids in brain function and structure. The fatty acid method can be used to identify enzyme targets of drugs acting on phospholipid metabolism. For example, a reduced brain turnover of arachidonate by chronic lithium, demonstrated in rats by the fatty acid method, suggests that this agent, which is used to treat bipolar disorder, has for its target an arachidonate-specific PLA2. In another context, when combined with in vivo imaging by quantitative autoradiography in rodents or positron emission tomography in macaques or humans, the fatty acid method can localize and quantify normal and modified PLA2-mediated signal transduction in brain.
Indexed as
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10555781What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.