ArticleThe American journal of pathology1999
Role of PDGF B-chain and PDGF receptors in rat tubular regeneration after acute injury.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
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- Potential targeted therapy and diagnosis based on novel insight into growth factors, receptors, and downstream effectors in acute kidney injury and acute kidney injury-chronic kidney disease progression.Signal transduction and targeted therapy · 2020Review
- Bioactive Compounds for the Treatment of Renal Disease.Yonsei medical journal · 2018Review
- Renal Interstitial Platelet-Derived Growth Factor Receptor-Journal of the American Society of Nephrology : JASN · 2018Article
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- Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis.International journal of molecular sciences · 2016Review
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- Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease.Nature reviews. Nephrology · 2014Review
- Regenerative medicine for the kidney: renotropic factors, renal stem/progenitor cells, and stem cell therapy.BioMed research international · 2014Review
- Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.The American journal of pathology · 2012Article
- The PDGF family in renal fibrosis.Pediatric nephrology (Berlin, Germany) · 2012Review
- A purpose-synthesised anti-fibrotic agent attenuates experimental kidney diseases in the rat.PloS one · 2012Article
- Acute kidney injury: a springboard for progression in chronic kidney disease.American journal of physiology. Renal physiology · 2010Review
- Dietary fructose causes tubulointerstitial injury in the normal rat kidney.American journal of physiology. Renal physiology · 2010Article
- Immunohistochemical study on caveolin-1alpha in regenerating process of tubular cells in gentamicin-induced acute tubular injury in rats.Virchows Archiv : an international journal of pathology · 2007Article
- Ischemia induces early expression of a new transcription factor (6A3-5) in kidney vascular smooth muscle cells: studies in rat and human renal pathology.The American journal of pathology · 2003Article
- Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury.The American journal of pathology · 2003Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various polypeptide growth factors are generally considered to be involved in the regulation of the nephrogenic process both after acute renal injury and during renal development. Because platelet-derived growth factor B-chain (PDGF-B) has been reported to be expressed in immature tubulus of the developing kidney, PDGF-B could play a role in the process of tubulogenesis. We examined the expression of PDGF-B and PDGF receptors alpha and beta and their localization in kidneys after ischemia/reperfusion injury. The mRNA expressions of PDGF-B, PDGFR-alpha, and PDGFR-beta were enhanced after injury. In the immunohistochemical analysis and/or in situ hybridization, PDGF-B and PDGFR-alpha, beta were expressed after reperfusion in the S3 segment of the proximal tubuli, where they were not expressed normally. The expressions of proliferating cell nuclear antigen and vimentin were concomitantly observed with PDGF-B and PDGFRs in the tubular cells of injured S3 segment at 48 hours after injury. Next, the inhibition of the PDGF-B/PDGFRs axis with either Trapidil or Ki6896, which was found to inhibit the phosphorylation of PDGFR-beta selectively, resulted in a rise of serum creatinine, higher mortality rate, abnormal regenerating process, and suppressed proliferation of tubular epithelial cells. These findings suggest that the PDGF-B/PDGFRs axis is involved in the proliferation of injured tubular cells and plays an important role in the regeneration of tubular cells from acute ischemic injury.
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