ArticleThe American journal of pathology1999
Chromosomal imbalances in primary lymphomas of the central nervous system.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 68 citations in OpenAlex.
- Protein tyrosine phosphatase receptor type kappa (PTPRK) revisited: evolving insights into structure, function, and pathology.Journal of translational medicine · 2025Review
- Detection of diagnostic somatic copy number alterations from cerebrospinal fluid cell-free DNA in brain tumor patients.Acta neuropathologica communications · 2024Article
- Review
- Clinicopathological features of primary central nervous system diffuse large B cell lymphoma: Experience from a Tertiary Center in North India.Surgical neurology international · 2020Article
- Introduction of novel agents in the treatment of primary CNS lymphoma.Neuro-oncology · 2019Review
- Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5.BioMed research international · 2013Article
- Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma.Leukemia · 2009Article
- Del(6)(q22) and BCL6 rearrangements in primary CNS lymphoma are indicators of an aggressive clinical course.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2008Article
- [Extranodal diffuse large B-cell lymphoma--an organotypic disease?].Der Pathologe · 2007Article
- Primary central nervous system lymphoma expressing the human neurotropic polyomavirus, JC virus, genome.Journal of virology · 2004Article
- Article
- Analysis of chromosomal copy number changes and oncoprotein expression in primary central nervous system lymphomas: frequent loss of chromosome arm 6q.Virchows Archiv : an international journal of pathology · 2003Article
- Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases.The American journal of pathology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twenty-two primary central nervous system lymphomas of immunocompetent adults were studied by comparative genomic hybridization. All were high-grade diffuse large B cell lymphomas. Comparative genomic hybridization revealed an average of 5.5 chromosomal changes per tumor, with gains being more common than losses (3.5 vs. 2.0). The most frequent DNA copy number changes were gains on chromosomes 1, 12, 18 (41% each), 7 (23%), and 11 (18%) and losses involving chromosomes 6 (59%), 18, and 20 (18% each). Commonly involved regions were +12q (41%), +18q (36%), +1q (32%), and +7q (23%), as well as -6q (50%), -6p (18%), -17p, and -18p (14% each). High-level gains were found on 7 chromosomes, mainly involving chromosomes 18q (23%), 12q (18%), and 1q (14%). Minimal common regions of over- and underrepresentation were found on +1q25-31, -6q16-21, +7q11.2, +12p11.2-13, +12q12-14, +12q22-24.1, and +18q12.2-21.3. A significant correlation between loss of DNA copy numbers on chromosome 6q and shorter survival could be established (10.2 vs. 22.3 months; P < 0.05). Our findings suggest that chromosomal imbalances of primary central nervous system lymphomas are similar to those of diffuse large B cell lymphomas at other locations and are probably not related to cerebral presentation; however, they may be prognostically relevant.
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