ArticleThe American journal of pathology1999
MYCN gene amplification. Identification of cell populations containing double minutes and homogeneously staining regions in neuroblastoma tumors.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Accurate Measurement of Cell Number-Normalized Differential Gene Expression in Cells Treated With Retinoic Acid.Bio-protocol · 2024Article
- Extrachromosomal DNA in cancer.Nature reviews. Cancer · 2024Review
- Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing.Redox biology · 2022Article
- Gene regulation on extrachromosomal DNA.Nature structural & molecular biology · 2022Review
- A sketch of known and novel MYCN-associated miRNA networks in neuroblastoma.Oncology reports · 2017Article
- Super-Enhancer-Driven Transcriptional Dependencies in Cancer.Trends in cancer · 2017Review
- Amplification of Cellular Oncogenes in Solid Tumors.North American journal of medical sciences · 2015Review
- Mitochondrial ferritin, a new target for inhibiting neuronal tumor cell proliferation.Cellular and molecular life sciences : CMLS · 2015Article
- Chemoresistance, cancer stem cells, and miRNA influences: the case for neuroblastoma.Analytical cellular pathology (Amsterdam) · 2015Review
- An Introspective Update on the Influence of miRNAs in Breast Carcinoma and Neuroblastoma Chemoresistance.Genetics research international · 2014Review
- Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons.Cancer research · 2013Article
- Novel functional MAR elements of double minute chromosomes in human ovarian cells capable of enhancing gene expression.PloS one · 2012Article
- Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure.Genome research · 2010Article
- Double minutes, cytogenetic equivalents of gene amplification, in human neoplasia - a review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2005Review
- MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study.Leukemia · 2000Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroblastoma is the second most common solid tumor occurring in children. Amplification of the MYCN oncogene is associated with poor prognosis. To identify neuroblastoma tumors with MYCN amplification, we studied the number of copies of MYCN in interphase cells by fluorescence in situ hybridization in 20 neuroblastoma patients. MYCN amplification appeared in 7 tumor specimens. Interphase and metaphase studies showed a tumor cell population with both forms of amplification, double minutes and homogeneously staining regions, in two patients. These patients showed a smaller tumor cell subpopulation with the presence of more than one homogeneously staining region, suggesting that gene amplification was undergoing karyotype evolution.
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