ArticleBMJ (Clinical research ed.)1999
Vertical transmission rates for HIV in the British Isles: estimates based on surveillance data.
Article in BMJ (Clinical research ed.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 86 citations in OpenAlex.
- Five year follow up of vertically HIV infected children in a randomised double blind controlled trial of immediate versus deferred zidovudine: the PENTA 1 trial.Archives of disease in childhood · 2001Trial
- Overall Vertical Transmission of Hepatitis C Virus, Transmission Net of Clearance, and Timing of Transmission.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Induced abortions of women living with HIV in Finland 1987-2019: a national register study.BMC pregnancy and childbirth · 2023Article
- Trends in management and outcomes of pregnant women living with HIV between 2008-2013 and 2014-2019: A retrospective cohort study.Frontiers in medicine · 2022Article
- An observational study of initial HIV RNA decay following initiation of combination antiretroviral treatment during pregnancy.AIDS research and therapy · 2020Observational
- Factors Associated with Maternal-Child Transmission of HIV-1 in Southeastern Brazil: A Retrospective Study.AIDS and behavior · 2018Article
- Pregnancy and neonatal outcomes among a cohort of HIV-infected women in a large Italian teaching hospital: a 30-year retrospective study.Epidemiology and infection · 2017Article
- UK national clinical audit: management of pregnancies in women with HIV.BMC infectious diseases · 2017Article
- Article
- Maternal and foetal outcomes among 4118 women with HIV infection treated with lopinavir/ritonavir during pregnancy: analysis of population-based surveillance data from the national study of HIV in pregnancy and childhood in the United Kingdom and Ireland.BMC infectious diseases · 2016Observational
- Comparison of auditory brainstem response in HIV-1 exposed and unexposed newborns and correlation with the maternal viral load and CD4+ cell counts.AIDS (London, England) · 2014Article
- The impact of African ethnicity and migration on pregnancy in women living with HIV in the UK: design and methods.BMC public health · 2012Article
- Incidence, patterns, and predictors of repeat pregnancies among HIV-infected women in the United Kingdom and Ireland, 1990-2009.Journal of acquired immune deficiency syndromes (1999) · 2012Article
- Use of zidovudine-sparing HAART in pregnant HIV-infected women in Europe: 2000-2009.Journal of acquired immune deficiency syndromes (1999) · 2011Article
- Routine antenatal HIV testing: the responses and perceptions of pregnant women and the viability of informed consent. A qualitative study.Journal of medical ethics · 2007Article
- Beyond counting cases: public health impacts of national Paediatric Surveillance Units.Archives of disease in childhood · 2007Article
- Estimating adult HIV prevalence in the UK in 2003: the direct method of estimation.Sexually transmitted infections · 2006Article
- Monitoring the effectiveness of HIV and STI prevention initiatives in England, Wales, and Northern Ireland: where are we now?Sexually transmitted infections · 2006Article
- Recent trends in HIV and other STIs in the United Kingdom: data to the end of 2002.Sexually transmitted infections · 2004Review
- Advances in the prevention and treatment of paediatric HIV infection in the United Kingdom.Sexually transmitted infections · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo estimate and interpret time trends in vertical transmission rates for HIV using data from national obstetric and paediatric surveillance registers.
designProspective study of HIV infected women reported through obstetric surveillance. HIV infection status of the child and onset of AIDS were reported through paediatric surveillance. Rates of vertical transmission and progression to AIDS rate were estimated by methods that take account of incomplete follow up of children with indeterminate infection status and delay in AIDS reporting.
settingBritish Isles. SUBJECTS: Pregnant women infected with HIV whose infection was diagnosed before delivery, and their babies.
main outcome measuresMother to child transmission of infection and progression to AIDS in children.
resultsBy January 1999, 800 children born to diagnosed HIV infected women who had not breast fed had been reported. Vertical transmission rates rose to 19.6% (95% confidence interval 8. 0% to 32.5%) in 1993 before falling to 2.2% (0% to 7.8%) in 1998. Between 1995 and 1998 use of antiretroviral treatment increased significantly each year, reaching 97% of live births in 1998. The rate of elective caesarean section remained constant, at around 40%, up to 1997 but increased to 62% in 1998. Caesarean section and antiretroviral treatment together were estimated to reduce risk of transmission from 31.6% (13.6% to 52.2%) to 4.2% (0.8% to 8.5%). The proportion of infected children developing AIDS in the first 6 months fell from 17.7% (6.8% to 30.8%) before 1994 to 7.2% (0% to 15. 7%) after, coinciding with increased use of prophylaxis against Pneumocystis carinii pneumonia.
conclusionsIn the British Isles both HIV related morbidity and vertical transmission are being reduced through increased use of interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.