ArticleClinical and diagnostic laboratory immunology1999
Comparison and characterization of immunoglobulin G subclasses among primate species.
Article in Clinical and diagnostic laboratory immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 80 citations in OpenAlex.
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- Comparative Analysis of Cellular Immune Responses in Conventional and SPF Olive Baboons (Comparative medicine · 2020Article
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- Translational Model of Zika Virus Disease in Baboons.Journal of virology · 2018Article
- Maternal Vaccination With a Monocomponent Pertussis Toxoid Vaccine Is Sufficient to Protect Infants in a Baboon Model of Whooping Cough.The Journal of infectious diseases · 2018Article
- Evaluation of an outbred mouse model for Francisella tularensis vaccine development and testing.PloS one · 2018Article
- Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression.Gene therapy · 2015Article
- Maternal and neonatal vaccination protects newborn baboons from pertussis infection.The Journal of infectious diseases · 2014Article
- Evaluation of a multivalent vaccine against lymphatic filariasis in rhesus macaque model.PloS one · 2014Article
- Age- and gender-associated changes in the concentrations of serum TGF-1β, DHEA-S and IGF-1 in healthy captive baboons (Papio hamadryas anubis).General and comparative endocrinology · 2014Article
- Antibody quality and protection from lethal Ebola virus challenge in nonhuman primates immunized with rabies virus based bivalent vaccine.PLoS pathogens · 2013Article
- The effect of season on inflammatory response in captive baboons.Journal of medical primatology · 2012Article
- A three-dose intramuscular injection schedule of anthrax vaccine adsorbed generates sustained humoral and cellular immune responses to protective antigen and provides long-term protection against inhalation anthrax in rhesus macaques.Clinical and vaccine immunology : CVI · 2012Article
- Review
- Lung dendritic cell developmental programming, environmental stimuli, and asthma in early periods of life.Journal of allergy · 2012Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Little information is available on the immunoglobulin G (IgG) subclasses expressed in the sera of nonhuman primate species. To address this issue, we compared the IgG subclasses found in humans (IgG1, IgG2, IgG3, and IgG4) to those of nonhuman primates, such as baboons and macaques. Cross-reactive antihuman IgG subtype-specific reagents were identified and used to analyze purified IgG from sera by solid-phase enzyme-linked immunosorbent assay. Protein A-purified human IgG obtained from sera was composed of IgG1, IgG2, IgG3, and IgG4, whereas baboon and macaque IgG was composed of IgG1, IgG2, and IgG4. Protein G-purified human IgG was composed of IgG1, IgG2, IgG3, and IgG4, whereas baboon and macaque IgG was composed of IgG1, IgG2, and IgG4. To test the possibility that baboon and macaque IgG3 is actually present, but is outcompeted for binding to proteins A and G by the other more abundant IgG subclasses, we repurified the IgG from sera that did not bind either protein A or protein G. We found a baboon IgG3 population in the sera that did not bind protein A, but bound protein G. No IgG3 subtype was detectable in macaque sera. These data suggest that baboon sera, like human sera, contain four IgG subtypes, whereas macaque sera exhibit only three of the human subclass analogs. In addition, the IgG subtype-specific reagents were shown to be useful in determining the IgG subclass distribution following vaccination of baboons with hepatitis B surface antigen.
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