ArticleThe Biochemical journal1999
Transport activity of AE3 chloride/bicarbonate anion-exchange proteins and their regulation by intracellular pH.
Article in The Biochemical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Who cites it
33 citing papers in PubMed, 97 citations in OpenAlex.
- Article
- The structural insight into the functional modulation of human anion exchanger 3.Nature communications · 2024Article
- A guide to plasma membrane solute carrier proteins.The FEBS journal · 2021Review
- Hydrogen, Bicarbonate, and Their Associated Exchangers in Cell Volume Regulation.Frontiers in cell and developmental biology · 2021Article
- Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70.The Journal of biological chemistry · 2019Article
- Functional assessment of SLC4A11, an integral membrane protein mutated in corneal dystrophies.American journal of physiology. Cell physiology · 2016Article
- Investigation of SLA4A3 as a candidate gene for human retinal disease.Journal of negative results in biomedicine · 2016Article
- Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation.The Journal of physiology · 2015Article
- Intracellular pH regulation by acid-base transporters in mammalian neurons.Frontiers in physiology · 2014Review
- The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters.Physiological reviews · 2013Review
- SLC4 family transporters in a marine diatom directly pump bicarbonate from seawater.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Quantification of carbonic anhydrase gene expression in ventricle of hypertrophic and failing human heart.BMC cardiovascular disorders · 2013Article
- Functional rescue of a kidney anion exchanger 1 trafficking mutant in renal epithelial cells.PloS one · 2013Article
- Short-term ionic plasticity at GABAergic synapses.Frontiers in synaptic neuroscience · 2012Article
- SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization.American journal of physiology. Cell physiology · 2011Article
- Cytosolic H+ microdomain developed around AE1 during AE1-mediated Cl-/HCO3- exchange.The Journal of physiology · 2011Article
- Article
- A SLC4-like anion exchanger from renal tubules of the mosquito (Aedes aegypti): evidence for a novel role of stellate cells in diuretic fluid secretion.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Sensors and regulators of intracellular pH.Nature reviews. Molecular cell biology · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma membrane Cl(-)/HCO(3)(-) anion-exchange (AE) proteins contribute to regulation of intracellular pH (pH(i)). We characterized the transport activity and regulation by pH(i) of full-length AE3 and the cardiac isoform, AE3c, both of which are expressed in the heart. AE3c is an N-terminal variant of AE3. We also characterized AE1, AE2 and a deletion construct (AE3tr) coding for the common region of AE3 and AE3c. AE proteins were expressed by transient transfection of HEK-293 cells, and transport activity was monitored by following changes of intracellular pH or intracellular chloride concentration associated with anion exchange. Transport activities, measured as proton flux (mM H(+).min(-1)), were as follows: AE1, 24; AE2, 32; full-length AE3, 9; AE3c, 4 and AE3tr, 4. The wide range of transport activities is not explained by variation of cell surface processing since approx. 30% of each isoform was expressed on the cell surface. pH(i) was clamped at a range of values from 6.0-9.0 to examine regulation of AE proteins by pH(i). Whereas AE2 was steeply inhibited by acid pH(i), AE1, AE3 and AE3c were essentially insensitive to changes of pH(i). We conclude that AE3 and AE3c can contribute to pH(i) recovery after cellular-acid loading.
Indexed as
Identifiers
10548554PMC1220634W2028348861What OpenQuestion holds
Registered trials
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