ArticleInternational ophthalmology
Retinal toxicity of liposome-incorporated and free ofloxacin after intravitreal injection in rabbit eyes.
Article in International ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 44 citations in OpenAlex.
- Transcriptomics and systems biology identify non-antibiotic drugs for the treatment of ocular bacterial infection.iScience · 2022Article
- Recent Updates on Treatment of Ocular Microbial Infections by Stem Cell Therapy: A Review.International journal of molecular sciences · 2018Review
- The dangers of sublethal carvacrol exposure: increases in virulence ofInternational journal of biochemistry and molecular biology · 2018Article
- Pharmacokinetics of intravenously administered tigecycline in eye compartments: an experimental study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Article
- Nanocarriers of nanotechnology in retinal diseases.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society · 2014Review
- Liposomes and nanotechnology in drug development: focus on ocular targets.International journal of nanomedicine · 2013Review
- Transporter targeted gatifloxacin prodrugs: synthesis, permeability, and topical ocular delivery.Molecular pharmaceutics · 2012Article
- A review on composite liposomal technologies for specialized drug delivery.Journal of drug delivery · 2011Article
- Ciprofloxacin as ocular liposomal hydrogel.AAPS PharmSciTech · 2010Article
- Toward improving therapeutic regimens for Bacillus endophthalmitis.Investigative ophthalmology & visual science · 2008Article
- Bacterial endophthalmitis: epidemiology, therapeutics, and bacterium-host interactions.Clinical microbiology reviews · 2002Review
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundOfloxacin (OFLX) is a fluoroquinolone-antibiotic with a broad antimicrobial spectrum that may have a potential role in the treatment of bacterial endophthalmitis. However, its elimination half life after intravitreal injection is short. To prolong the intravitreal antibacterial level OFLX was incorporated into liposomes. This study was performed to investigate the retinal toxicity of liposome-incorporated and free OFLX. MATERIALS AND
methodsOFLX was incorporated into multilamellar large vesicles. 0.1 ml of this suspension (= 180.2 microg OFLX) was injected into the midvitreous of rabbit eyes (n = 6). Free OFLX in doses of 100 microg, 500 microg and 1,000 microg was injected into the midvitreous of a second group of rabbit eyes (n = 18). The other eye served as a control and received empty liposomes or normal saline solution, respectively. Before injection and at the end of follow-up an ERG was obtained. After a follow-up of 1 day, 14 and 28 days the animals were perfused with glutaraldehyde and the eyes were examined by light- and transmission electron microscopy.
resultsThe ERG as well as the histologic studies did not reveal any pathological changes after injection of liposome-incorporated OFLX compared to the control eyes. Significant reduction of the ERG was observed after 500 microg free OFLX in 2 out of 6 eyes after 1 and 14 days, respectively, and in 2 eyes 1 day after 1,000 microg free OFLX. Three days after injection of 1,000 microg OFLX the retina showed focal destruction in 1 out of 6 eyes. In another eye with the same dose 14 days after injection the photoreceptor outer segments showed disorganisation.
conclusionThis study shows that liposome-incorporated OFLX did not have any retinal toxicity in this animal model. Free OFLX appears to have no retinal toxicity in rabbit eyes at a dose of 100 microg after intravitreal injection. Injection of higher doses resulted in ERG changes and marked retinal damage.
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