ArticleDigestive diseases and sciences1999
Experimental liver injury induced by Propionibacterium acnes and lipopolysaccharide in macrophage colony stimulating factor-deficient osteopetrotic (op/op) mice.
Article in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 citing papers in PubMed, 14 citations in OpenAlex.
- Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- FR167653 attenuates murine immunological liver injury.World journal of gastroenterology · 2004Article
- Leflunomide attenuates hepatocyte injury by inhibiting Kupffer cells.World journal of gastroenterology · 2004Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To clarify the involvement of growth and differentiation of liver macrophages mediated by macrophage colony-stimulating factor (M-CSF) in the liver injury induced by Propionibacterium acnes (P. acnes) and lipopolysaccharide (LPS), we used M-CSF-deficient osteopetrotic (op/op) mice. Seven days after injection of P. acnes, granulomas as well as the numbers of Thy-1.2-, Mac-1-, and ERMP-20-positive cells and F4/80-positive areas in the liver were significantly reduced in the op/op mice compared to the normal littermates. After injection of LPS, serum levels of alanine aminotransferase as well as concentrations of IL-1beta and TNF-alpha in the serum and liver were significantly lower in the op/op mice than in the normal littermates, whereas the concentrations of IL-1beta and TNF-alpha in the spleen were similar in op/op mice and normal littermates. These results suggest that M-CSF plays a partial but highly significant role in the development of liver injury induced by P. acnes and LPS via an intrahepatic increase of primed macrophages including those in granulomas, in response to P. acnes, which produce proinflammatory cytokines such as IL-1beta and TNF-alpha.
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