ArticleNature1999
En passant neurotrophic action of an intermediate axonal target in the developing mammalian CNS.
Article in Nature, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The Role of Apoptotic Signaling in Axon Guidance.Journal of developmental biology · 2018Review
- How to survive a nerve-wracking journey.eLife · 2013Article
- Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons.eLife · 2013Article
- Blocking apoptotic signaling rescues axon guidance in Netrin mutants.Cell reports · 2013Article
- Elimination of aberrant DRG circuitries in Sema3A mutant mice leads to extensive neuronal deficits.PloS one · 2013Article
- The effects of target skeletal muscle cells on dorsal root ganglion neuronal outgrowth and migration in vitro.PloS one · 2013Article
- Expression of mRNAs for PPT, CGRP, NF-200, and MAP-2 in cocultures of dissociated DRG neurons and skeletal muscle cells in administration of NGF or NT-3.Folia histochemica et cytobiologica · 2012Article
- Quantitative analysis by in vivo imaging of the dynamics of vascular and axonal networks in injured mouse spinal cord.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Transient cell-cell interactions in neural circuit formation.Nature reviews. Neuroscience · 2009Review
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- Article
- A novel role for jun N-terminal kinase signaling in olfactory sensory neuronal death.Molecular and cellular neurosciences · 2008Article
- Macrophage-derived tumor necrosis factor alpha, an early developmental signal for motoneuron death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Regulation of neuronal survival and death by extracellular signals during development.The EMBO journal · 2003Review
- Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Molecular genetics of cranial nerve development in mouse.Nature reviews. Neuroscience · 2001Review
- Netrin-1 acts as a survival factor via its receptors UNC5H and DCC.The EMBO journal · 2001Article
Corrections and comments
- Commented on by
- Expression of concern
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During development, neurons extend axons to their targets, then become dependent for their survival on trophic substances secreted by their target cells. Competition for limiting amounts of these substances is thought to account for much of the extensive naturally-occurring cell death that is seen throughout the nervous system. Here we show that spinal commissural neurons, a group of long projection neurons in the central nervous system (CNS), are also dependent for their survival on trophic support from one of their intermediate targets, the floor plate of the spinal cord. This dependence occurs during a several-day-long period when their axons extend along the floor plate, following which they develop additional trophic requirements. A dependence of neurons on trophic support derived en passant from their intermediate axonal targets provides a mechanism for rapidly eliminating misprojecting neurons, which may help to prevent the formation of aberrant neuronal circuits during the development of the nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.