ArticleGenetics1999
Unusual haplotype structure at the proximal breakpoint of In(2L)t in a natural population of Drosophila melanogaster.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A cosmopolitan inversion facilitates seasonal adaptation in overwintering Drosophila.Genetics · 2024Pooled it
- Chromosomal Inversions in Chromosome U ofInsects · 2025Article
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- Extensive Recombination Suppression and Epistatic Selection Causes Chromosome-Wide Differentiation of a Selfish Sex Chromosome inGenetics · 2020Article
- Article
- The molecular genealogy of sequential overlapping inversions implies both homologous chromosomes of a heterokaryotype in an inversion origin.Scientific reports · 2019Article
- Muller "Elements" inGenetics · 2018Article
- Linked genetic variation and not genome structure causes widespread differential expression associated with chromosomal inversions.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Frequencies of chromosomal inversions in Drosophila melanogaster in Fukushima after the nuclear power plant accident.PloS one · 2018Article
- Inversion evolutionary rates might limit the experimental identification of inversion breakpoints in non-model species.Scientific reports · 2017Article
- The Effect of Common Inversion PolymorphismsG3 (Bethesda, Md.) · 2017Article
- An easy route to the massive karyotyping of complex chromosomal arrangements in Drosophila.Scientific reports · 2017Article
- Genomic Trajectories to Desiccation Resistance: Convergence and Divergence Among Replicate Selected Drosophila Lines.Genetics · 2017Article
- Multiple and diverse structural changes affect the breakpoint regions of polymorphic inversions across the Drosophila genus.Scientific reports · 2016Article
- Cross-Study Comparison Reveals Common Genomic, Network, and Functional Signatures of Desiccation Resistance in Drosophila melanogaster.Molecular biology and evolution · 2016Article
- Reconciling Differences in Pool-GWAS Between Populations: A Case Study of Female Abdominal Pigmentation in Drosophila melanogaster.Genetics · 2016Article
- Putative adaptive inter-slope divergence of transposon frequency in fruit flies (Drosophila melanogaster) at "Evolution Canyon", Mount Carmel, Israel.Biology direct · 2015Article
- A molecular perspective on a complex polymorphic inversion system with cytological evidence of multiply reused breakpoints.Heredity · 2015Article
- Global diversity lines - a five-continent reference panel of sequenced Drosophila melanogaster strains.G3 (Bethesda, Md.) · 2015Article
- Mechanisms of naturally evolved ethanol resistance in Drosophila melanogaster.The Journal of experimental biology · 2014Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The existence of temporally stable frequency clines for In(2L)t in natural populations of Drosophila melanogaster suggests a role for selection in the maintenance of this polymorphism. We have collected nucleotide polymorphism data from the proximal breakpoint junction regions of In(2L)t to infer its evolutionary history. The finding of a novel LINE-like element near the In(2L)t breakpoint junction in sampled inverted chromosomes supports a transposable element-mediated origin for this inversion. An analysis of nucleotide variation in a Costa Rican population sample of standard and inverted chromosomes indicates a unique and relatively recent origin for In(2L)t. Additional In(2L)t alleles from three geographically diverse populations reveal no detectable geographic differentiation. Low levels of In(2L)t nucleotide polymorphism suggest a recent increase in the inversion's frequency in tropical populations. An unusual feature of our sample of standard alleles is a marked heterogeneity in levels of linkage disequilibrium among polymorphic sites across the breakpoint region. We introduce a test of neutral equilibrium haplotype structure that corrects both for multiple tests and for an arbitrarily chosen window size. It reveals that an approximately 1.4-kb region immediately spanning the breakpoint has fewer haplotypes than expected under the neutral model, given the expected level of recombination in this genomic region. Certain features of our data suggest that the unusual pattern in standard chromosomes is the product of selection rather than demography.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.