ArticleGenetics1999
Local recombination and mutation effects on molecular evolution in Drosophila.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Meiotic, genomic and evolutionary properties of crossover distribution in Drosophila yakuba.PLoS genetics · 2022Article
- Variation in the Intensity of Selection on Codon Bias over Time Causes Contrasting Patterns of Base Composition Evolution in Drosophila.Genome biology and evolution · 2017Article
- Molecular Evolutionary Consequences of Island Colonization.Genome biology and evolution · 2016Article
- The role of GC-biased gene conversion in shaping the fastest evolving regions of the human genome.Molecular biology and evolution · 2012Article
- Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster.Genome biology and evolution · 2009Article
- Estimating selection intensity on synonymous codon usage in a nonequilibrium population.Genetics · 2009Article
- Strong evidence for lineage and sequence specificity of substitution rates and patterns in Drosophila.Molecular biology and evolution · 2009Article
- Article
- Recurrent events of positive selection in independent Drosophila lineages at the spermatogenesis gene roughex.Genetics · 2008Article
- Article
- The other side of the nearly neutral theory, evidence of slightly advantageous back-mutations.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
- Reduced efficacy of selection in regions of the Drosophila genome that lack crossing over.Genome biology · 2007Article
- Fine-scale crossover rate heterogeneity in Drosophila pseudoobscura.Journal of molecular evolution · 2007Article
- Strong regional heterogeneity in base composition evolution on the Drosophila X chromosome.Genetics · 2006Article
- Article
- A cis-regulatory sequence within the yellow locus of Drosophila melanogaster required for normal male mating success.Genetics · 2006Article
- Codon bias and noncoding GC content correlate negatively with recombination rate on the Drosophila X chromosome.Journal of molecular evolution · 2005Article
- Multilocus analysis of introgression between two sympatric sister species of Drosophila: Drosophila yakuba and D. santomea.Genetics · 2005Article
- Patterns of selection on synonymous and nonsynonymous variants in Drosophila miranda.Genetics · 2005Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
I studied the cause of the significant difference in the synonymous-substitution pattern found in the achaete-scute complex genes in two Drosophila lineages, higher codon bias in Drosophila yakuba, and lower bias in D. melanogaster. Besides these genes, the functionally unrelated yellow gene showed the same substitution pattern, suggesting a region-dependent phenomenon in the X-chromosome telomere. Because the numbers of A/T --> G/C substitutions were not significantly different from those of G/C --> A/T in the yellow noncoding regions of these species, a AT/GC mutational bias could not completely account for the synonymous-substitution biases. In contrast, we did find an approximately 14-fold difference in recombination rates in the X-chromosome telomere regions between the two species, suggesting that the reduction of recombination rates in this region resulted in the reduction of the efficacy of selection in D. melanogaster. In addition, the D. orena yellow showed a 5% increase in the G + C content at silent sites in the coding and noncoding regions since the divergence from D. erecta. This pattern was significantly different from those at the orena Adh and Amy loci. These results suggest that local changes in recombination rates and mutational pressures are contributing to the irregular synonymous-substitution patterns in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.