ArticleGenetics1999
The Saccharomyces cerevisiae RanGTP-binding protein msn5p is involved in different signal transduction pathways.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Karyopherin Msn5 is involved in a novel mechanism controlling the cellular level of cell cycle regulators Cln2 and Swi5.Cell cycle (Georgetown, Tex.) · 2019Article
- Experimental testing of a new integrated model of the budding yeast Start transition.Molecular biology of the cell · 2015Article
- Proteins interacting with mitochondrial ATP-dependent Lon protease (MAP1) in Magnaporthe oryzae are involved in rice blast disease.Molecular plant pathology · 2015Article
- Protein disorder reduced in Saccharomyces cerevisiae to survive heat shock.F1000Research · 2015Article
- Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.Microbiology and molecular biology reviews : MMBR · 2012Review
- The karyopherin Kap95 and the C-termini of Rfa1, Rfa2, and Rfa3 are necessary for efficient nuclear import of functional RPA complex proteins in Saccharomyces cerevisiae.DNA and cell biology · 2011Article
- Acidic calcium stores of Saccharomyces cerevisiae.Cell calcium · 2011Review
- Common genetic pathways regulate organ-specific infection-related development in the rice blast fungus.The Plant cell · 2010Article
- Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiae.The Journal of cell biology · 2003Article
- Cell cycle activation of the Swi6p transcription factor is linked to nucleocytoplasmic shuttling.Molecular and cellular biology · 2003Article
- Osmotic stress signaling and osmoadaptation in yeasts.Microbiology and molecular biology reviews : MMBR · 2002Review
- Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site.Genes & development · 2002Article
- Regulatory elements in the FBP1 promoter respond differently to glucose-dependent signals in Saccharomyces cerevisiae.The Biochemical journal · 2001Article
- Article
- The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins.The Journal of cell biology · 2001Article
- Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p.Genes & development · 1999Article
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Authors and funding
4 authors.
Funding
Abstract
In eukaryotes, control of transcription by extracellular signals involves the translocation to the nucleus of at least one component of the signal transduction pathway. Transport through the nuclear envelope requires the activity of an import or export receptor that interacts with the small GTPase Ran. We have cloned the MSN5 gene of the yeast Saccharomyces cerevisiae that is postulated to encode one of these receptors. Msn5p belongs to a family of proteins with a conserved N-terminal sequence that acts as a RanGTP-binding domain. The results presented here provide genetic data supporting Msn5p involvement in several different signal transduction pathways. All of these pathways include changes in gene expression, and regulated nucleocytoplasmic redistribution of a component in response to external conditions has already been described in some of them. We have cloned MSN5 following two different strategies. Msn5p was constitutively localized in the nucleus. Phenotypic analysis of the msn5 mutant demonstrated that this protein participates in processes such as catabolite repression, calcium signaling, mating, and cell proliferation, as well as being involved in previously characterized phosphate utilization. Therefore, Msn5p could be a receptor for several proteins involved in different signaling pathways.
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