ArticleBiophysical journal1999
Molecular dynamics of synthetic leucine-serine ion channels in a phospholipid membrane.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Transcendent Aspects of Proton Channels.Annual review of physiology · 2024Review
- Water in Nanopores and Biological Channels: A Molecular Simulation Perspective.Chemical reviews · 2020Review
- Review
- Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Validity of the Electrodiffusion Model for Calculating Conductance of Simple Ion Channels.The journal of physical chemistry. B · 2017Article
- Synthesis, lipid membrane incorporation, and ion permeability testing of carbon nanotube porins.Nature protocols · 2016Article
- Philosophy of voltage-gated proton channels.Journal of the Royal Society, Interface · 2014Review
- Benchmark Study of the SCC-DFTB Approach for a Biomolecular Proton Channel.Journal of chemical theory and computation · 2014Article
- Molecular dynamics simulations of homo-oligomeric bundles embedded within a lipid bilayer.Biophysical journal · 2013Article
- Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family.Physiological reviews · 2013Review
- Modulation of the conductance of a 2,2'-bipyridine-functionalized peptidic ion channel by Ni2+.European biophysics journal : EBJ · 2008Article
- Charge delocalization in proton channels, II: the synthetic LS2 channel and proton selectivity.Biophysical journal · 2007Article
- Protons may leak through pure lipid bilayers via a concerted mechanism.Biophysical journal · 2005Article
- Distribution of pentachlorophenol in phospholipid bilayers: a molecular dynamics study.Biophysical journal · 2004Article
- Theory and simulation of water permeation in aquaporin-1.Biophysical journal · 2004Article
- A computer simulation study of the hydrated proton in a synthetic proton channel.Biophysical journal · 2003Article
- Pores formed by the nicotinic receptor m2delta Peptide: a molecular dynamics simulation study.Biophysical journal · 2003Article
- Analysis and evaluation of channel models: simulations of alamethicin.Biophysical journal · 2002Article
- K(+) versus Na(+) ions in a K channel selectivity filter: a simulation study.Biophysical journal · 2002Article
- Molecular dynamics simulations of wild-type and mutant forms of the Mycobacterium tuberculosis MscL channel.Biophysical journal · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Molecular dynamics calculations were carried out on models of two synthetic leucine-serine ion channels: a tetrameric bundle with sequence (LSLLLSL)(3)NH(2) and a hexameric bundle with sequence (LSSLLSL)(3)NH(2). Each protein bundle is inserted in a palmitoyloleoylphosphatidylcholine bilayer membrane and solvated by simple point charge water molecules inside the pore and at both mouths. Both systems appear to be stable in the absence of an electric field during the 4 ns of molecular dynamics simulation. The water motion in the narrow pore of the four-helix bundle is highly restricted and may provide suitable conditions for proton transfer via a water wire mechanism. In the wider hexameric pore, the water diffuses much more slowly than in bulk but is still mobile. This, along with the dimensions of the pore, supports the observation that this peptide is selective for monovalent cations. Reasonable agreement of predicted conductances with experimentally determined values lends support to the validity of the simulations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.