ArticleBiophysical journal1999
A thermodynamic model for receptor clustering.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Divalent ligand-monovalent molecule binding.Soft matter · 2021Article
- Development of Nascent Focal Adhesions in Spreading Cells.Biophysical journal · 2020Review
- Article
- Cargo binding promotes KDEL receptor clustering at the mammalian cell surface.Scientific reports · 2016Article
- The efficiency of reactant site sampling in network-free simulation of rule-based models for biochemical systems.Physical biology · 2011Article
- Monte Carlo simulations of plasma membrane corral-induced EGFR clustering.Journal of biotechnology · 2011Article
- Adaptive coarse-grained Monte Carlo simulation of reaction and diffusion dynamics in heterogeneous plasma membranes.BMC bioinformatics · 2010Article
- Expanding the utility of beta-galactosidase complementation: piece by piece.Molecular pharmaceutics · 2010Article
- The network of receptors characterize B cell receptor micro- and macroclustering in a Monte Carlo model.The journal of physical chemistry. B · 2010Article
- Modeling multivalent ligand-receptor interactions with steric constraints on configurations of cell-surface receptor aggregates.Biophysical journal · 2010Article
- Collective equilibrium behaviour of ion channel gating in cell membranes: an ising model formulation.Journal of biological physics · 2006Article
- Tandem gramicidin channels cross-linked by streptavidin.The Journal of general physiology · 2003Article
- A statistical mechanics model for receptor clustering.Journal of biological physics · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties of this cooperative process clearly affect the signal transduction. Recent investigations have revealed the molecular basis of receptor-receptor interactions, but a simple theoretical framework for using these data to predict cluster formation has been lacking. Here, we propose a simple, coarse-grained, phenomenological model for ligand-modulated receptor interactions and discuss its equilibrium properties via mean-field theory. The existence of a first-order transition for this model has immediate implications for the robustness of the cellular signaling response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.