ArticleBiophysical journal1999
Numerical simulation of Ca2+ "sparks" in skeletal muscle.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 66 citations in OpenAlex.
- Voltage sensing mechanism in skeletal muscle excitation-contraction coupling: coming of age or midlife crisis?Skeletal muscle · 2018Review
- Calcium-induced release of calcium in muscle: 50 years of work and the emerging consensus.The Journal of general physiology · 2018Review
- Article
- Calcium waves initiating from the anomalous subdiffusive calcium sparks.Journal of the Royal Society, Interface · 2014Article
- Microdomain calcium fluctuations as a colored noise process.Frontiers in genetics · 2014Article
- Evoked centripetal Ca(2+) mobilization in cardiac Purkinje cells: insight from a model of three Ca(2+) release regions.The Journal of physiology · 2013Article
- Intracellular calcium movements during excitation-contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers.The Journal of general physiology · 2012Review
- Properties of Ca2+ sparks revealed by four-dimensional confocal imaging of cardiac muscle.The Journal of general physiology · 2012Article
- Age-related regulation of excitation-contraction coupling in rat heart.Journal of physiology and biochemistry · 2011Article
- Stochastic simulation of calcium microdomains in the vicinity of an L-type calcium channel.European biophysics journal : EBJ · 2010Article
- Model Convolution: A Computational Approach to Digital Image Interpretation.Cellular and molecular bioengineering · 2010Article
- Low-affinity Ca2+ indicators compared in measurements of skeletal muscle Ca2+ transients.Biophysical journal · 2009Article
- Calcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians.The Journal of general physiology · 2008Article
- Elementary Ca2+ release events in mammalian skeletal muscle: effects of the anaesthetic drug thiopental.Journal of muscle research and cell motility · 2006Article
- Altered elementary calcium release events and enhanced calcium release by thymol in rat skeletal muscle.Biophysical journal · 2004Article
- Imaging single cardiac ryanodine receptor Ca2+ fluxes in lipid bilayers.Biophysical journal · 2004Article
- Voltage-dependent Ca2+ fluxes in skeletal myotubes determined using a removal model analysis.The Journal of general physiology · 2004Article
- Ca2+ sparks and embers of mammalian muscle. Properties of the sources.The Journal of general physiology · 2003Article
- Mechanisms of microtubule-based kinetochore positioning in the yeast metaphase spindle.Biophysical journal · 2003Article
- Simulation of calcium sparks in cut skeletal muscle fibers of the frog.The Journal of general physiology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A three dimensional (3D) model of Ca(2+) diffusion and binding within a sarcomere of a myofibril, including Ca(2+) binding sites troponin, parvalbumin, sarcoplasmic reticulum Ca(2+) pump, and fluorescent Ca(2+)-indicator dye (fluo-3), was developed to numerically simulate laser scanning confocal microscope images of Ca(2+) "sparks" in skeletal muscle. Diffusion of free dye (D), calcium dye (CaD), and Ca(2+) were included in the model. The Ca(2+) release current was assumed to last 8 ms, to arise within 4 x 10(-5) microm(3) at the triad and to be constant during release. Line scan confocal fluorescence images of Ca(2+) sparks were simulated by 3D convolution of the calculated distribution of CaD with a Gaussian kernel approximating the point spread function of the microscope. Our results indicate that the amplitude of the simulated spark is proportional to the Ca(2+) release current if all other model parameters are constant. For a given release current, the kinetic properties and concentrations of the binding sites and the diffusion parameters of D, CaD, and Ca(2+) all have significant effects on the simulated Ca(2+) sparks. The simulated sparks exhibited similar amplitudes and temporal properties, but less spatial spread than experimentally observed sparks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.